Volume 16, Number 1 (8-2017)                   ijdld 2017, 16(1): 1-8 | Back to browse issues page


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Mohammadi R, Matin Homaee H, Azerbaijani , M A, Baesi K. EFFECT OF 12 WEEK RESISTANCE TRAINING ON GENE EXPRESSIONS RAGE, ICAM, VCAM IN THE HEART OF DIABETIC RATS WITH STZ. ijdld. 2017; 16 (1) :1-8
URL: http://ijdld.tums.ac.ir/article-1-5505-en.html

1- Department of Exercise Physiology, Faculty of Physical Education, Islamic Azad University, Central Tehran Branch, Tehran, Iran , Rasoul.mohammadi141@gmail.com
2- Department of Exercise Physiology, Faculty of Physical Education, Islamic Azad University, Central Tehran Branch, Tehran, Iran
3- Department of Virology, Pasteur Institute of Iran, Tehran, Iran
Abstract:   (692 Views)

Background: Cardiomyopathy is a side effect caused by diabetes. Prolonged hyperglycemia gives rise to an increase in the expression of the receiver gene RAGE subsequently triggering pathogenesis cardiac signaling pathways in the heart of rats with type II diabetes. The present paper aims to examine how a 12 week Resistance training on gene expressions RAGE, ICAM, VCAM in the heart of diabetic rats with STZ.
Methods: 16 male Wistar rats with weight mean ranging from 200 ± 20 g were randomly assigned to two groups of Resistance diabetes (n = 8) and control diabetes (n = 8) and were kept under lab circumstances. A 12 week Resistance training was administered with the experimental group and 48 hours after the end of the last training session the rats were made unconscious and examined. Their hearts were, afterwards, cut out and the extent of gene expressions RAGE, ICAM, VCAM in the left ventricular heart was measured using Real time-PCR method.
Results: The results indicated there was a significant difference between left ventricular heart of the Resistance diabetes and that of control diabetes in terms of gene expression RAGE, yet no significant difference was detected between the two groups in terms of gene expressions ICAM, VCAM.
Conclusion: According to the results, in seems that Resistance trainings effectively reduce gene expressions RAGE and reduction pattern but non-significant in the Gene ICAM, VCAM in left ventricular heart of diabetic rats and therefore can be considered an effective way in reducing pathogenesis cardiac signaling pathways in the heart of rats with type II diabetes.

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Type of Study: Research | Subject: Special
Received: 2016/04/23 | Accepted: 2016/12/4 | Published: 2017/08/28

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