Volume 7, Number 2 (17 2007)                   ijdld 2007, 7(2): 229-237 | Back to browse issues page


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Mirarefin M, Aminpour A, Fakhrzadeh H, Tahbaz F, Abadi A. THE EFFECT OF FOLATE FORTIFIED BREAD ON HOMOCYSTEINE, FOLATE AND VITAMIN B12 STATUS AMONG HYPERHOMOCYSTEINEMIC SUBJECTS: TEHRAN HOMOCYSTEINE STUDY. ijdld. 2007; 7 (2) :229-237
URL: http://ijdld.tums.ac.ir/article-1-285-en.html

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Abstract:   (3978 Views)

Background: Fortification of corn with folic acid has beneficial effects on hyperhomocysteinemia and heart disease. Folate fortification was contributed to an increase in average folate status and a reduction in serum homocysteine concentration.

Methods: In this randomized clinical trial 17 men and women aged 61±5 years old with hyperhomocysteinemia with mean homocysteine concentration of 15/32±6/13 µmol/L were recruited. Subjects received fortified bread which contained 100µg folic acid daily for 8 weeks. Three-day food record, food frequency questionnaire and BMI (Body Mass Index) data at baseline and week 8 were completed. Plasma homocysteine and serum folate at baseline and week 8 were measured. All dietary and statistical analyses were undertaken using Nutritionist III and SPSS release 15.0 software with paired t-test.

Results: Mean plasma homocysteine concentration decreased significantly in hyperhomocysteinemic subjects after daily consumption of folate fortified bread for 8 weeks (P<0.001).After 8 weeks serum folate concentration increased %26 (P=0.06). Mean BMI, energy and other components of dietary intake did not change significantly. Dietary vitamin C decreased significantly (P<0.001).

Conclusion: Daily consumption of folic acid fortified bread, with 100 µg folic acid, in hyperhomocysteinemic subjects for 8 weeks led to significant decrease in plasma homocysteine and an increase in serum folate.

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Type of Study: Research | Subject: General
Received: 2007/12/27 | Accepted: 2008/02/16 | Published: 2013/10/15

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