Volume 6, Number 3 (17 2007)                   ijdld 2007, 6(3): 225-234 | Back to browse issues page


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Sharifi A M, Ghaderpanahi M, Mazhari S Z H. THE EFFECT OF L - CARNITINE ON SERUM NITRIC OXIDE LEVEL AND ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN STZ - INDUCED DIABETIC AND NORMAL RATS. ijdld. 2007; 6 (3) :225-234
URL: http://ijdld.tums.ac.ir/article-1-314-en.html

Abstract:   (4864 Views)

Background: Cardiovascular disease including hypertension are complications of long-standing diabetes. A few Studies had shown the positive effects of L-carnitine on hypertension. In this study, the possible effects of L-carnitne on nitric oxide (NO) levels and angiotensin-converting enzyme (ACE) activity in serum as well as systolic blood pressure (SBP) in diabetic and normal rats were studied.

Methods: In this study forty rats were used in four groups including non-treated control (C), L-carnitne treated control (CT), diabetic (D) and L-carnitne treated diabetic (DT). Diabetes was induced in rats by injection of stereptozotosin. Both of C & D groups had a free access to food and water and CT & DT groups were received daily dose of L-carnation in drinking water. At the end of 12 weeks SBP, serum NO and ACE activity were measured.

Results: Systolic blood pressure was significantly decreased in DT group compared to D group. Serum ACE activity was also significantly decreased in DT group compared to D group and the serum NO levels were significantly increased in DT & CT groups compared to D & C groups respectively.

Conclusion: Finally it could be concluded that L-carnitine may reduce SBP in diabetic rats via elevation of serum NO levels and reduction of serum ACE activity.

Full-Text [PDF 279 kb]   (780 Downloads)    
Type of Study: Research | Subject: General
Received: 2007/02/5 | Accepted: 2007/04/21 | Published: 2013/10/15

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