Volume 6, Number 2 (18 2006)                   ijdld 2006, 6(2): 135-141 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rouini M, Sadray S, H. Ardakani Y, Mokhberi M, Solmaz S. PHARMACOKINETIC AND PHARCODYNAMIC EVALUATION OF METFORMIN HCL 500 MG TABLET AMONG HEALTHY VOLUNTEERS. ijdld. 2006; 6 (2) :135-141
URL: http://ijdld.tums.ac.ir/article-1-5070-en.html

Abstract:   (3400 Views)
Background: Metformin is used in treatment of non-insulin-dependent diabetes mellitus (NIDDM). The present study was aimed to study the pharmacokinetic and pharmaco-dynamic of metformin 500 mg tablet in healthy volunteers.
Methods: The test and reference metformin hydrochloride 500 mg tablets were administered to 12 healthy volunteers in a cross-over study. Metformin serum concentration and decrease in blood sugar levels (dBSL) were used for study of pharmacokinetic and pharmacodynamic.
Results: There was no correlation between phramacodynamic and pharmacokinetic para-meters. Also there was no increase in dBSL-(AUC0-12) with increase metformin serum concentration-time. The results of our study show that both products could be bioequivalent according to serum concentration and not blood sugar data.
Conclusion: There was no concentration – effect (dBSL) correlation for both products. Metformin didn’t decrease the blood glucose in healthy volunteers. In some volunteers there was no increase in blood sugar after meal and dextrose 20% oral solution administration which could be related to decreased absorption of glucose from gastrointestinal tract caused by metformin.
Full-Text [PDF 234 kb]   (735 Downloads)    
Type of Study: Research | Subject: General
Received: 2006/12/11 | Accepted: 2007/03/9 | Published: 2013/10/14

Add your comments about this article : Your username or email:
Write the security code in the box

© 2017 All Rights Reserved | Iranian Journal of Diabetes and Metabolism

Designed & Developed by : Yektaweb