Volume 13, Number 2 (1-2014)                   ijdld 2014, 13(2): 102-110 | Back to browse issues page


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Aveseh M, Nikooie R, Atabi F, Mirzaie zadeh Z, Omidfar K, Larijani B. THE EFFECT OF SEVEN WEEKS ENDURANCE TRAINING ON RBP4 GENE EXPRESSION IN SKELETAL MUSCLE IN TYPE 2 DIABETIC RATS. ijdld. 2014; 13 (2) :102-110
URL: http://ijdld.tums.ac.ir/article-1-5106-en.html

1- Shahid Bahonar University of kerman, Faculty of physical education and sport science, Kerman, Iran
2- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute,Tehran University of Medical Sciences, Tehran, Iran
3- Biosensor Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4- Biosensor Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , omidfar@tums.ac.ir
5- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (3679 Views)
Background: the aim of this study was to investigate the effect of seven weeks endurance training on RBP4 gene expression in Soleus and Extensor Digitrum Longouse (EDL) Muscles, liver, visceral and subcutaneous fat in type 2 diabetic rats. Methods: 50 male wistar rats (5 weeks years old, weight = 93.7 ± 8.9) were purchased and randomly divided into four groups: Control (n=10) (C), Trained (n=10) (T), Diabetic Control (n=15) (DC) and Trained diabetic (n=15) (TD). Diabetes was induced by injection of low dose of streptozotocin (STZ) and feeding with high fat diet. Insulin resistance accuracy was confirmed by HOMA-IR index and Real-time PCR was used for mRNA content. Results: After seven weeks of diabetes induction, the RBP4 mRNA content of the liver (2.37-fold P < 0.01), visceral fat (2.33-fold P < 0.01), and subcutaneous fat (1.83-fold P < 0.05), soleus (1.21-fold P < 0.05) and EDL (2.03-fold P < 0.05) were increased. After seven weeks of endurance training significant decrease in RBP4 mRNA content was found in visceral fat (P < 0.05), subcutaneous fat (P < 0.05) and EDL (P < 0.05) between DC and CD. In addition, significant difference between T and TD groups was found for RBP4 mRNA content in liver (p < 0.01), subcutaneous fat (P < 0.01) and EDL (P < 0.01) after seven weeks of endurance training. Conclusion: Type 2 diabetes considerably increases skeletal muscle RBP4 expression in isoform- specific manner. This increase is also seen in liver, subcutaneous and visceral fat. In addition, endurance training decreases the RBP4 expression in EDL, subcutaneous and visceral fat.
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Type of Study: Research | Subject: General
Received: 2014/03/4 | Accepted: 2014/03/4 | Published: 2014/03/4

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