Iranian Journal of

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Background: It is now evident that adipose tissue functions as an endocrine organ by releasing adipokines, and the levels of a number of inflammatory markers elevated in overweight and obese individuals. The objective of this study was to examine the association between inflammatory markers (IMs) including C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Homocystein (Hcy) and obesity variables in Tehran Lipid and Glucose Study (TLGS) adults. Methods: In this cross-sectional study, 352 individuals (132 men and 220 women), age ≥19 years, were randomly recruited from among TLGS population. Individuals were categorized based on the waist circumference. The serum levels of IMs were determined using the Enzyme Linked Immunosorbent Assay (ELISA) method. Results: The mean age of participants was 46.1±16.1years and Abdominal obesity were present in 199(56.5%) individuals. The levels of hs-CRP and IL-6 were higher in abdominally obese group (1507±3.3 vs. 577.8±4.3 ng/mL p<0.001) (3.6±3.3 vs. 1.9±3.8 pg/mL p< 0.001), and in the same group, the best predictors (based on the adjusted R2) for hs-CRP, IL-6 and Hcy were waist (WC), waist to height ratio (WHtR) and wrist, respectively. Hip and WHtR were the best predictors for Hcy and hs-CRP in normal group there was no variable significantly correlated with IL-6, therefore it was not possible to consider an independent predictor for IL-6. Conclusion: According to this study, obesity is associated with IM levels, and in abdominally obese group, the best predictor for Hcy, hs-CRP and IL-6 were Wrist, waist and WHtR respectively.

Keywords: hs-CRP, IL-6, Hcy, abdominal obesity, and TLGS

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