Volume 13, Number 5 (7-2014)                   ijdld 2014, 13(5): 383-392 | Back to browse issues page


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Yaghmaei P, Abbasi F, Ebrahim-Habibi A, Hesaraki A. THE EFFECT OF BISPHENOL A AND BISPHENOL AP IN A MOUSE MODEL OF POLYCYSTIC OVARY SYNDROME. ijdld. 2014; 13 (5) :383-392
URL: http://ijdld.tums.ac.ir/article-1-5250-en.html

1- 1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2- 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , f_abbasi@sina.tums.ac.ir
Abstract:   (2420 Views)

  Background : PCOS (Polycystic Ovary Syndrome = PCOS) is a relatively common disease in women of childbearing age. Bisphenol s are chemical groups that are composed of two functional hydroxyl group and most of them are based on methane. In this study, the effects of phenolic compounds, (bisphenol A and AP) in polycystic ovary syndrome were investigated.

  Methods : mature Wister rats were classified in six groups . Healthy controls ( healthy rats that received Grape seed Oil as solvent ), PCOS Group ( disease induced by testosterone propionate ) experimental groups 1.2.3.4 , respectively. after induction of PCOS,they received bisphenol- A and AP in doses of25 mg / kg, 50mg/kg, by gavage . Blood samples were taken and the hormones LH, FSH was measured . Ovaries were also to be studied histologically .

  Results : The results showed that the amount of LH to FSH ratio increases after induction with bisphenol-A and bisphenols AP,. Furthermore the number of follicles and growing follicles were reduced significantly, and these concequences causing negative effects on polycystic ovary syndrome.

 

Full-Text [PDF 618 kb]   (997 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/11/1 | Accepted: 2014/11/1 | Published: 2014/11/1

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