Volume 13, Number 5 (7-2014)                   ijdld 2014, 13(5): 425-433 | Back to browse issues page


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Baziar N, DJafarian K, Shadman Z, Qorbani M, Khoshniat Nikoo M, Razi F. EFFECT OF VITAMIN D SUPPLEMENTATION ON IMPROVING VITAMIN D LEVELS AND INSULIN RESISTANCE IN VITAMIN D INSUFFICIENT OR DEFFICIENT TYPE2 DIABETICS. ijdld. 2014; 13 (5) :425-433
URL: http://ijdld.tums.ac.ir/article-1-5260-en.html

1- 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2- 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3- 3. Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
4- 5. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (3230 Views)
Background: Vitamin D deficiency is associated with impaired insulin secretion, glucose intolerance and type 2 diabetes. This study was conducted to investigate the effects of supplementation with 50,000 IU vitamin D on improving serum vitamin D levels and insulin resistance in vitamin D insufficient or deficient type 2 diabetic patients. Methods: In this double blind randomized clinical trial, 81 type 2 diabetic patients with vitamin D levels between 10-30 ng/ml were randomly assigned to intervention (50,000 IU vitamin D3 once a week) and control (placebo once a week) groups according to gender. The study duration was 8 weeks. At the beginning and the end of study, blood samples were collected after 12 hours overnight fasting and fasting serum glucose, insulin and 25-hydroxyvitamin D were measured. Insulin resistance was obtained by HOMA-IR calculation. Results: After 8 weeks supplementation with vitamin D, 25-hydroxyvitamin D level was significantly increased and reached to normal levels in the intervention group. Fasting serum glucose and insulin concentrations and HOMA-IR were significantly decreased in the vitamin D group, but there were no significant changes in the placebo group. Conclusion: Supplementation with 50,000 IU vitamin D for 8 weeks compared to placebo can improve inadequate levels of vitamin D and glycemic indicators in vitamin D insufficient or deficient type 2 diabetic patients.
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Type of Study: Research | Subject: General
Received: 2014/11/11 | Accepted: 2014/11/11 | Published: 2014/11/11

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