Volume 16, Issue 2 (1-2017)
ijdld 2017, 16(2): 85-93 |
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1- Department of Exercise Physiology, faculty of Physical Education and Sport Sciences, Alzahra University, Tehran, Iran , kazemi.fahimeh@yahoo.de
2- Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract: (4362 Views)
Background: Recently the role of apelin in inflammation has been known. However, the effect of exercise training-induced cytokine apelin in diabetes status hasn’t been investigated. The purpose of this study was to determine the atni-inflammation effect of 8-week aerobic training on apelin plasma concentration in diabetic male rats.
Methods: Twenty eight diabetic male Wistar rats were randomly divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide (95 mg/kg body weight) and streptozotocin (60 mg/kg body weight). The training group ran 8-week on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the training, plasma concentrations of glucose, insulin, TNF-α and apelin were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson’s correlation was used for analyzing data. P<0.05 was considered to be statistically significant.
Results: Results showed a significant decrease in plasma concentrations of glucose, insulin and TNF-α and HOMA-IR in trained diabetic vs control diabetic group, a significant increase in plasma concentration of apelin in trained diabetic group vs non-diabetic and control diabetic group and a significant negative correlation between plasma concentrations of apelin and TNF-α in trained diabetic group.
Conclusion: It appears that 8-week aerobic training by improvement of insulin sensitivity and decrease of inflammation can increase plasma concentration of apelin in diabetic male rats.
Methods: Twenty eight diabetic male Wistar rats were randomly divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide (95 mg/kg body weight) and streptozotocin (60 mg/kg body weight). The training group ran 8-week on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the training, plasma concentrations of glucose, insulin, TNF-α and apelin were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson’s correlation was used for analyzing data. P<0.05 was considered to be statistically significant.
Results: Results showed a significant decrease in plasma concentrations of glucose, insulin and TNF-α and HOMA-IR in trained diabetic vs control diabetic group, a significant increase in plasma concentration of apelin in trained diabetic group vs non-diabetic and control diabetic group and a significant negative correlation between plasma concentrations of apelin and TNF-α in trained diabetic group.
Conclusion: It appears that 8-week aerobic training by improvement of insulin sensitivity and decrease of inflammation can increase plasma concentration of apelin in diabetic male rats.
Type of Study: Research |
Subject:
Special
Received: 2014/11/16 | Accepted: 2015/02/25 | Published: 2017/09/26
Received: 2014/11/16 | Accepted: 2015/02/25 | Published: 2017/09/26
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