Volume 15, Issue 5 (7-2016)                   ijdld 2016, 15(5): 292-299 | Back to browse issues page


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Mortezaee M, Raz A, Mansouri S, Annabestani Z, Mirzaeezadeh Z, Larijani B, et al . Assessment Of The Relationship Between Two Single Nucleotide Polymorphisms Of Rbp4 Genes With Diabetic Foot Ulcer In Type 2 Diabetic Patients Referred To The Clinic Of Diabetes And Metabolic Diseases. ijdld. 2016; 15 (5) :292-299
URL: http://ijdld.tums.ac.ir/article-1-5444-en.html

1- Islamic Azad University, Tehran Medical Branch, Iran.
2- Malaria and Vector Research Group (MVRG), Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran
3- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4- Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5- Biosensor Research Center, Endocrinology and Metabolism Molecular–Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6- Islamic Azad University, Tehran Medical Branch, Iran
7- Biosensor Research Center, Endocrinology and Metabolism Molecular–Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , omidfar@tums.ac.ir
Abstract:   (2367 Views)

Background: Insulin resistance and progressive β-cells failure are the key factors in type 2 diabetes mellitus (T2DM) pathogenesis. Many studies support a primary role of RBP4 in insulin resistance and suggest that genetic variations which alter the expression level of RBP4 might influence the risk of T2DM and its complications. Diabetic foot is one of the main complications of diabetes leading to disability and hospitalization. In addition, it reduces quality of life and imposes great cost to patients. The purpose of this study was to evaluate the correlation between two single nucleotide polymorphisms (rs10882273 and rs10882283) of RBP4 genes with diabetic foot ulcer in order to identify a biomarker for prediction of diabetic foot ulcer.

Methods: This is a case-control study. Two single nucleotide polymorphisms of RBP4 genes were genotyped by hit Tetra ARMS PCR technique. In this study, 100 and 133 diabetic patients with and without foot ulcer were selected as the cases and controls, respectively.

Results: The Chi-square test revealed no significant difference in frequency of TT, CC and TC alleles of rsl0882273 between case and control groups (P=0.414). Also, Comparison of AA, CC and AC alleles of rsl0882283 in both groups did not show significant difference (P=0.85).
Conclusion: According to this study, there is no relationship between two single nucleotide polymorphisms of RBP4 genes (rs10882273 and rs10882283) with diabetic foot ulcer in type2 diabetes patients.
Full-Text [PDF 467 kb]   (750 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/11/11 | Accepted: 2016/01/25 | Published: 2016/11/22

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