Iranian Journal of

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Background: the aim of the present study was to investigate the effects of diabetes and seven weeks of endurance training on RBP4 expression in Soleus, extensor digiturom longuse (EDL), liver, visceral and subcutaneous fat in type 2 diabetic rats. Methods: Fifty male wistar rats (93.7 ± 8.9 g) were randomly divided into four groups including: control (C) [n=10], trained (T) [n=10], diabetic control (DC) [n=15] and diabetic trained (TD) [n=15]. The combination of Intraperitoneally injection of streptozotocin (STZ) and high fat diet feeding were used for diabetes induction. After seven weeks of endurance training, serum RBP4 and its expression in above tissues were measured by ELISA and western blotting techniques, respectively. Results: diabetes induction increased the RBP4 expression of the liver (3.57-fold, p < 0.01), visceral fat (2.02-fold, p < 0.01), and subcutaneous fat (1.84-fold, p < 0.01) and EDL (2.29-fold, p < 0.01) in DC in comparison to C group. Serum RBP4 concentration was significantly higher in DC (2.9-fold, p < 0.01) and TD (1.84-fold, p < 0.01) in comparison to C group. Endurance training significantly decreased serum RBP4 (p < 0.01) and its expression in visceral fat (p < 0.01) in DT in comparison to DC. Conclusion: type 2 diabetes extensively decreases the skeletal muscle RBP4 expression in isoform – specific manner, liver, subcutaneous and visceral fat. In addition, endurance training decreases serum RBP4 concentration and its expression in visceral fat.

Keywords: type 2 diabetes, endurance training. RBP4

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