Volume 13, Issue 5 (7-2014)
ijdld 2014, 13(5): 400-412 |
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Monazzami A, Rajabi H, Omidfar K, Mostafaie A. ENDURANCE TRAINING INCREASES SKELETAL MUSCLE NA/H+ EXCHANGER1 (NHE1) AND NA/HCO3 CO-TRANSPORTER1 (NBC1) GENE EXPRESSIONS IN TYPE2 DIABETIC RAT. ijdld 2014; 13 (5) :400-412
URL: http://ijdld.tums.ac.ir/article-1-5252-en.html
URL: http://ijdld.tums.ac.ir/article-1-5252-en.html
1- 1. Assistant professor in Sport Physiology, Department of Physical Education and Sport Sciences, University of Razi, Kermanshah, Iran , monazzami.amirabbas@gmail.com
2- 2. Associate professor in Sport Physiology, Department of Physical Education and Sport Sciences, University of Tarbiat Moallem, Tehran , Iran
3- 3. Biosensor Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, University ofTehran Medical Sciences, Tehran, Iran
4- 4. Professor in Immunology, Department of Immunology, University of Medical Sciences, Kermanshah, Iran
2- 2. Associate professor in Sport Physiology, Department of Physical Education and Sport Sciences, University of Tarbiat Moallem, Tehran , Iran
3- 3. Biosensor Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, University ofTehran Medical Sciences, Tehran, Iran
4- 4. Professor in Immunology, Department of Immunology, University of Medical Sciences, Kermanshah, Iran
Abstract: (6585 Views)
Background: The purpose of this study was to investigate the effects of endurance training on muscle NHE1 and NBC1 gene expressions in type 2 diabetic rats.
Methods: Male wistar rats (n=40), 4weeks old and 93.7±9.8g, were randomly selected and divided into control, diabetic control and diabetic training groups. The Endurance training was performed for 7 weeks on diabetic training groups (running on treadmill forrodent). NHE1 and NBC1 gene expression were determined by Realtime-PCR technique. The differences between groups in variables were determined by an independent t-test using REST Software.
Results: NHE1 mRNA expression reduced significantly in EDL and Soleus by 25% and 19% in the diabetic control group compared with the control group, respectively (P<0/05).NHE1 mRNA expression also reduced significantly in EDL and Soleus by 35% and 29% in the diabetic control group compared with the control group, respectively (P<0/05).Endurance training increased NHE1 and NBC1 geneexpressions in both EDL and Soleus in the diabetic training group.
Conclusion: The present study showed that NHE1 and NBC1 mRNA expressions decreased significantly in the diabetic control group and endurance training increased NHE1 and NBC1 mRNA expressions in the diabetic trained group leading to normalizing the mRNAs in diabetic trained group.
Type of Study: Research |
Subject:
General
Received: 2014/11/1 | Accepted: 2014/11/1 | Published: 2014/11/1
Received: 2014/11/1 | Accepted: 2014/11/1 | Published: 2014/11/1
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