Background: Type 2 diabetes is a chronic disease that leads to many complications such as atherosclerosis. Matrix Metalloproteinase (MMPs) family plays a key role in atherosclerosis and remodeling of the vessel wall. The aim of this study was determination the Effect of eight weeks aerobic exercise with Portulaca oleracea seeds consumption on MMP-1, MMP-3 and MIP-1α in women with type 2 diabetes.

Methods: In one Quasi-experimental study 28 women with type II diabetes (44 to 65 years old) selected and divided into 4 groups (Exercise, Supplement, Exercise-Supplement and Control groups) randomly. Exercise program included 8 weeks (3 sessions per week) with 50 to 70% of maximum heart rate. Supplemented groups received 7.5 g Portulaca oleracea seeds every day. Blood samples were collected before and after the 8 weeks with 12 hours fasting conditions. P < 0.05 considered statistically significant.

Results: Eight weeks of the aerobic training or portulacalo consumption cause a significant decrease in MMP-1، MMP-3 و MIP-1α levels, in comparison to pretest. However, the effectiveness of combination training and supplement is better in the above indicators. MMP-1 levels showed a significant difference between supplement, training, training- supplement group with control group (P = 0.001) and between supplement exercise group with training- supplement (Respectively P = 0.018, P =0.039). MMP-3 levels showed a significant difference between supplement with training- supplement (P = 0.007) and control group (P = 0.011), exercise group with training- supplement (P = 0.026) and control group (P = 0.04). MIP-1α levels showed a significant difference between training- supplement and control group (P = 0.001).

Conclusion: The results showed both intervention exercise and purslane may be support from due to the effects of antioxidant and anti-inflammatory from oxidative stress induced diabetes and combination therapy was associated with synergistic effects.