Volume 19, Issue 3 (2-2020)
ijdld 2020, 19(3): 114-122 |
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Bozorgnejad N, Aghaei Meybodi H R, Afshari M, Sarhangi N, Hasanzad M. ASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK. ijdld 2020; 19 (3) :114-122
URL: http://ijdld.tums.ac.ir/article-1-5945-en.html
URL: http://ijdld.tums.ac.ir/article-1-5945-en.html
Negin Bozorgnejad1 
, Hamid Reza Aghaei Meybodi2 , Mahdi Afshari3 , Negar Sarhangi2 , Mandana Hasanzad * 4
, Hamid Reza Aghaei Meybodi2 , Mahdi Afshari3 , Negar Sarhangi2 , Mandana Hasanzad * 4
1- Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran
4- Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran ,mandanahasanzad@yahoo.com
2- Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran
4- Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran ,
Abstract: (1596 Views)
Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes that was classically characterized by pancreatic β-cell dysfunction. Changes in circadian patterns is one of the reasons which can increase the occurrence of diabetes. Melatonin is one of the biological molecules which plays an important role in regulating the circadian clock and also an inhibitory effect on insulin secretion in β-cells. The aim of this study was to examine the association between MTNR1B (rs10830962) gene polymorphism and the risk of T2DM.
Methods: Genotyping was carried out in a total number of 208 subjects including 108 patients with T2DM and 100 normal controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) which is confirmed by Sanger sequencing method.
Results: The frequencies of CC, GC and GG among cases were 54.63%, 1.85% and 43.52% and in control subjects were 81%, 0% and 19% respectively (P<0.001). Frequency of G allele among diabetic patients was significantly higher than non-diabetics (OR=3.34, CI=2.10-5.36, P<0.001).
Conclusion: Our study showed that rs10830962 polymorphism of the MTNR1B gene can be directly associated with T2DM risk.
Methods: Genotyping was carried out in a total number of 208 subjects including 108 patients with T2DM and 100 normal controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) which is confirmed by Sanger sequencing method.
Results: The frequencies of CC, GC and GG among cases were 54.63%, 1.85% and 43.52% and in control subjects were 81%, 0% and 19% respectively (P<0.001). Frequency of G allele among diabetic patients was significantly higher than non-diabetics (OR=3.34, CI=2.10-5.36, P<0.001).
Conclusion: Our study showed that rs10830962 polymorphism of the MTNR1B gene can be directly associated with T2DM risk.
Type of Study: Research |
Subject:
Special
Received: 2020/05/17 | Accepted: 2020/08/19 | Published: 2020/02/29
Received: 2020/05/17 | Accepted: 2020/08/19 | Published: 2020/02/29
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