1- 1. Department of Sports Sciences, Ilam Branch, Islamic Azad University, Ilam, Iran
2- 1. Department of Sports Sciences, Ilam Branch, Islamic Azad University, Ilam, Iran ,m2omidi@yahoo.com
2- 1. Department of Sports Sciences, Ilam Branch, Islamic Azad University, Ilam, Iran ,
Abstract: (171 Views)
Introduction: Diabetes is a global epidemic and the most common metabolic disorder caused by impaired insulin secretion and glucose metabolism. The aim of this study was to investigate the effect of 8 weeks of aerobic training on serum levels of asprosin and insulin resistance index in diabetic rats.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250±20 grams. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P=0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P=0.048 and P=0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P=0.001 and P=0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250±20 grams. The program of aerobic exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software.
Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P=0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and insulin resistance in mice (P=0.048 and P=0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased insulin resistance in diabetic rats (P=0.001 and P=0.036, respectively).
Conclusion: Induced diabetes causes insulin resistance and increase in serum levels of asprosine, which can be improved by performing aerobic exercises.
Article number: 7
Keywords: Aerobic exercise, Wistar rat, type 2 diabetes mellitus, insulin resistance, asprosine hormone
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