Safdar Mahdavifard, Seyede Zahra Bathaie, Manouchehr Nakhjavani , Batoul Etemadi Kia,
Volume 13, Issue 4 (5-2014)
Abstract
Background: Diabetes is the most common metabolic diseases and its vascular complications are main cause of death in diabetic patients. Patients with hyperglycemia, dyslipidemia and oxidative stress are prone to diabetes complications. The goal of this study was investigation of the effect of cysteine (Cys) on hyperglycemia, lipid profile, atherogenic index, glyoxal, methylglyoxal, oxidative stress and, glycation and oxidation of LDL in the rat model of diabetes –atherosclerosis.
Methods: Diabetes was induced in the rats using Streptozotocin injection then they put on the atherogenic diet. The groups under study were including of control and diabetic rats, and two other similar groups under Cys (0.05 % in dirking water) treatment. After one month, fasting blood sugar (FBS), lipid profile, atherogenic index (LDL/HDL), glycated and oxidized LDL, AGEs, glyoxal, methylglyoxal, Advanced oxidation protein products (AOPP) as an oxidative stress index and weight of rat was measured.
Results: Diabetic-atherosclerotic rat groups significantly showed higher level of FBS, triglyceride, cholesterol, LDL, atherogenic index, glycated and oxidized LDL, glyoxal, methylglyoxal and AOPP than control group. These parameters significantly (P < 0.001) reduced in diabetic group treated with Cys in comparison of untreated.
Conclusion: Cysteine with improving property on glycemic and lipemic conditions, inhibitory activity on glycation and oxidation of LDL and reduction of oxidative stress in diabetic-atherosclerotic rats could recommended as a drug for prevention of diabetes complications.
Nadiyeh Mohammadpour, Zaher Etemad, Khalid Mohammadzade, Asieh Abbassi Daloii,
Volume 20, Issue 3 (2-2021)
Abstract
Background: The hepatokines are now considered potential targets for the treatment of type 2 diabetes disorders. The aim of this study was to investigate the effect of 12 weeks combined training with Canagliflozin on some hepatokines in type 2 diabetic men.
Methods: In this quasi-experimental study, 44 men with type 2 diabetes (Mean age 33.2 ± 4.5 years, body mass index 27.3±3.0) from Tehran city in 2019 were randomly divided into four groups (n=11) of control, drug, exercise and exercise-drug groups. Combined training was performed 3 sessions per week, 45 minutes for 12 weeks. Subjects were given 200 mg of canagliflozin for 12 weeks. Blood samples and anthropometric characteristics were obtained before and 24 hours after the intervention at 12-hour fasting. Data were analyzed using two-way ANOVA with repeated measures, t-test and Bonferroni post hoc test at P<0.05.
Results: The results showed that 12 weeks of exercise with Canagliflozin intervention significantly reduced angiopoietin-3 and angiopoietin-4, FGF-21 and HFREP-1 levels in type 2 diabetic men (P=0.001). Also, after the intervention of exercise with Canagliflozin, levels of angiopoietin-3, angiopoietin-4, FGF-21, and HFREP-1 were significantly lower than the pre-test (P<0.001).
Conclusion: According to the results of research, it is possible that intervention of exercise with Canagliflozin can help treat of disorders due to type 2 diabetes by reducing hepatokines.
