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TO DETERMINE THE EFFECTS OF SOY CONSUMPTION ON MARKERS OF INFLAMMATION AND ENDOTHELIAL FUNCTION IN POSTMENOPAUSAL WOMEN WITH THE METABOLIC SYNDROME
Leila Azadbakht, Masoud Kimiagar, Yadolah Mehrabi, Ahmad Esmaeil Zadeh,
Volume 6, Issue 4 (6-2007)
Abstract

Background: Recently on the metabolic syndrome is considered as an inflammatory disease. So factors affecting inflammation are important in this condition.

Methods: This randomized cross-over clinical trial was undertaken on 42 postmenopausal women with metabolic syndrome. Participants were randomly assigned to consume a control diet (Dietary Approaches to Stop Hypertension= DASH), soy protein diet, or soy nut diet, each for eight weeks. Inflammatory markers were measured by ELISA.

 Results: The difference from the control diet for E-selectin (an inflammatory markers which shows the endothelial function) was -11.4% (P<0.01) on the soy nut consumption and -4.7% (p=0.19) on the soy protein diets. Soy nut consumption reduced interleukin-18 compared to the control diet (difference from the control diet: -9.2%, p<0.01). For C-reactive protein the difference from the control diet was -8.9% (P<0.01) on the soy nut diet and -1.6% (P<0.01) on the soy protein diet.

Conclusion: Short-term soy nut consumption reduced some markers of inflammation and increased plasma nitric oxide levels in postmenopausal women with the metabolic syndrome.


Comparison of Mr-Proadm, No and Homa-Ir Responses to A Session of Submaximal Exercise in Athletes and Non-Athletes
Manijeh Namjoo, Parvaneh Nazarali, Rahman Soori, Azam Ramezankhani, Fatemeh Fallah,
Volume 22, Issue 4 (11-2022)
Abstract
Background: Adrenomodoline (ADM) is a multifunctional peptide involved in a wide range of physiological processes and cardiovascular function. The purpose of the present study was to compare the effect of physical activity on ADM and nitric oxide (NO) levels and insulin resistance in athletes and non-athletes.
Material and
Methods: 12 athletes and 11 non-athletes participated in this quasi-experimental study. Study participants were selected by convenience sampling.  Both groups performed the Bruce protocol. Blood samples were collected before and after the training session to study the variables. Data were analyzed using one-way analysis of covariance, paired t-test, independent t-test and Pearson correlation.
Results: The results showed that after one session of submaximal exercise activity, HOMA-IR index decreased in non-athlete group (P = 0.034) and NO values increased in both athlete and non-athlete groups (P = 0.001, P = 0.002) and this increase was greater in the athlete group. Also, serum ADM levels were increased in the non-athlete group (P = 0.001) after the training session.
Conclusion: The single session of physical activity with increasing ADM and NO levels, can lead to better vasodilation and improved endothelial function as well as improved insulin resistance in inactive individuals. Since in athletes, only NO levels increased after the end of the activity, it seems that PA has a greater effect on improving the endothelial function of inactive people.
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