fa ارزیابی فارماکوکینتیک و فارماکودینامیک قرص پانصد میلی گرمی متفورمین هیدروکلراید در داوطلبان سالم عمومى General پژوهشي Research <b>Background: </b>Metformin is used in treatment of non-insulin-dependent diabetes mellitus (NIDDM). The present study was aimed to study the pharmacokinetic and pharmaco-dynamic of metformin 500 mg tablet in healthy volunteers. <br><b>Methods:</b> The test and reference metformin hydrochloride 500 mg tablets were administered to 12 healthy volunteers in a cross-over study. Metformin serum concentration and decrease in blood sugar levels (dBSL) were used for study of pharmacokinetic and pharmacodynamic. <br><b>Results:</b> There was no correlation between phramacodynamic and pharmacokinetic para-meters. Also there was no increase in dBSL-(AUC0-12) with increase metformin serum concentration-time. The results of our study show that both products could be bioequivalent according to serum concentration and not blood sugar data. <br><b>Conclusion:</b> There was no concentration – effect (dBSL) correlation for both products. Metformin didn’t decrease the blood glucose in healthy volunteers. In some volunteers there was no increase in blood sugar after meal and dextrose 20% oral solution administration which could be related to decreased absorption of glucose from gastrointestinal tract caused by metformin. متفورمین هیدروکلراید ، فارماکو کینتیک ، فارماکودینامیک ، کاهش قند خون ، غلظت سرمی Metformin, Pharmacokinetic, Pharmacodynamic, Serum concentration, Blood sugar 135 141 http://ijdld.tums.ac.ir/browse.php?a_code=A-10-25-5042&slc_lang=fa&sid=1 Mohammad-Reza Rouini محمد رضا روئینی Yes Sima Sadray سیما صدرای No Yalda H. Ardakani یلدا حسین زاده اردکانی No Maryam Mokhberi مریم مخبری No Sedaghat Solmaz سولماز صداقت No