Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
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اثر 24 هفته مداخلهی تمرین تناوبی شدید و رژیمهای غذایی بر تغییرات شاخص اینترلوکین 6 در بیماران مرد دیابتی نوع دو چاق
THE EFFECT OF 24 WEEKS OF INTENSE INTERMITTENT EXERCISE AND DIET INTERVENTION ON CHANGES IN INTERLEUKIN 6 INDEX IN OBESE MALE PATIENTS WITH TYPE 2 DIABETES
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<strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">مقدمه: </span></span></span></strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">اختلال متابولیکی ناشی التهاب در اثر چاقی و دیابت افزایش می</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Calibri,sans-serif;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">یابد که از طریق ورزش و رژیم غذایی کنترل می</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Cambria,serif;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">شود. از این</span></span></span><span dir="LTR"><span style="color:black;"><span style="font-family:Calibri,sans-serif;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">رو هدف این پژوهش بررسی اثر 24 هفته مداخلهی تمرین</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">تناوبی شدید و رژیم</span></span></span><span style="color:black;"><span style="font-family:Cambria,serif;"><span style="font-size:12.0pt;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">های غذایی بر تغییرات شاخص اینترلوکین 6 در بیماران دیابتی نوع دو چاق است.</span></span></span><br>
<strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">روش</span></span></span></strong><strong><span dir="LTR"><span style="color:black;"></span></span></strong><strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">ها:</span></span></span></strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> 70 مرد</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">(بیمار دیابت نوع دو و چاق) بهصورت تصادفی به 7 گروه (4 گروه در رژیم غذایی متفاوت بهعلاوه مداخلهی</span></span></span><span dir="LTR"><span style="color:black;"> HIIT </span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">و 3 گروه تنها در رژیم غذایی متفاوت) که در برنامهی</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">غذایی 1200 تا 1900 کیلوکالری/روز برای هفته 24 شرکت کردند، در حالی که بیماران در برنامهی</span></span></span><span dir="LTR"><span style="color:black;"> HIIT </span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">تحت نظارت (12 هفتهای) قرار گرفتند که با 4 هفته رژیم</span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">های غذایی اولیه دنبال شد. شاخصهای آنتروپومتریکی، فیزیولوژیکی، ترکیب بدن و نمونهی خون ناشتای در هفته</span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">های 0 ، 4، 8، 14، 20 و 24 جمع</span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">آوری شدند</span></span></span><span dir="LTR"><span style="color:black;">.</span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"></span></span></span><br>
<strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">یافتهها:</span></span></span></strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> پس از اتمام 24 هفته مداخله، بیشترین درصد افزایش و کاهش</span></span></span><span dir="LTR"><span style="color:black;"> IL-6 </span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">بهترتیب به رژیم</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">غذایی پرچربی(80/19 </span></span></span><span style="color:black;"><span style="font-family:Cambria,serif;"><span style="font-size:12.0pt;">±</span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> 09/28) و رژیم</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">غذایی کم</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">کربوهیدرات+تمرین تناوبی (13/25 </span></span></span><span style="color:black;"><span style="font-family:Cambria,serif;"><span style="font-size:12.0pt;">±</span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> 89/28-) اختصاص داشت. پس از 12 هفته تمرین</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">تناوبی به همراه رژیم غذایی بیشترین درصد افزایش</span></span></span><span dir="LTR"><span style="color:black;"> IL-6 </span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">به گروه رژیم</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">غذایی پرچربی(33/25 </span></span></span><span style="color:black;"><span style="font-family:Cambria,serif;"><span style="font-size:12.0pt;">±</span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> 74/26) مرتبط است، با این وجود بیشترین درصد کاهش</span></span></span><span dir="LTR"><span style="color:black;"> IL-6</span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> مختص به گروه کم چربی+تمرین تناوبی (17/29 </span></span></span><span style="color:black;"><span style="font-family:Cambria,serif;"><span style="font-size:12.0pt;">±</span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> 11/32-) بود.</span></span></span><br>
<strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">نتیجهگیری:</span></span></span></strong><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> یافته</span></span></span><span style="color:black;"><span style="font-family:Cambria,serif;"><span style="font-size:12.0pt;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">ها نشان دادند که رژیم کم</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">کربوهیدرات و کم</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">چربی با </span></span></span><span dir="LTR"><span style="color:black;">HIIT</span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> و وعده</span></span></span><span style="color:black;"><span style="font-family:Cambria,serif;"><span style="font-size:12.0pt;"></span></span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">های کم</span></span></span> <span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;">کربوهیدرات همراه با </span></span></span><span dir="LTR"><span style="color:black;">HIIE</span></span><span style="color:black;"><span style="font-family:B Lotus;"><span style="font-size:12.0pt;"> ممکن است برای بیماران دیابت نوع دو چاق مفید باشد.</span></span></span>
<strong>Background:</strong> Inflammation is one of the main causes of obesity and type 2 diabetes due to obesity and can increase metabolic disorders. Because exercise and diet are effective in reducing inflammation, Hence, Present Study Examined the Effects Of 24 Weeks Interventions On IL-6 Index Changes in Obesity Type 2 Diabetic Men: Influenced by HIIT And Diet Regimes<br>
<strong>Methods:</strong> In this study, 70 men (Obese Type 2 Diabetic Patients) were randomly assigned into 7 groups (4 groups in different diet plus HIIT intervention and 3 groups only in different diet) that involved adherence to a 1,200 kcal/day for 1 week until 1,900 kcal/d diet for 24 weeks while participating in a supervised HIIT (12 week) followed with 4 weeks primarily diet regimes. Diet regimes consist of standard diet (50% CHO, 32% fat), low carbohydrate diet (25% CHO, 57% fat; 70% of 57% fat was unsaturated fat), low fat diet (67% CHO, 15% fat) and high fat (25% CHO, 57% fat; 50% of 57% fat was saturates fat), while protein was 18% for all groups. Anthropometrics and physiologies parameters, Body composition and fasting blood samples were obtained at 0, 4, 8, 14, 20 and 24 weeks. Data were analyzed by repeated measures analysis, one-way ANOVA test. Data are presented as mean±SD changes from baseline.<br>
<strong>Results:</strong> results indicated that between differences times wasn’t show significant different (F (5,315) =3.66; P=0.002; η2=0.055). also results demonstrated that within groups changes interactions don’t show significant different (F (5,315) =1.61; P=0.025; η2=0.133). This results also revelated that maximum increase and decrease of IL-6 was in high fat diet (28.09±19.80) and low CHO+HIIT (-28.89±25.13) after 24 weeks interventions. maximum increase and decrease of IL-6 was in high fat diet (26.74±25.33) and low fat +HIIT (-32.11±29.17) After 12 weeks HIIT + diet interventions.<br>
<strong>Conclusion:</strong> Results support contentions that different diet regimes and exercise were selectively affects Pro Inflammatory markers and that changes in low CHO and low fat plus HIIT and low CHO meals plus with HIIE may be benefit for obese type 2 diabetic patients
دیابت نوع دو, اینترلوکین 6, تمرین تناوبی با شدت بالا, چاقی
IL-6, HIIT, Diet, Obesity, T2D
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http://ijdld.tums.ac.ir/browse.php?a_code=A-10-801-3&slc_lang=fa&sid=1
Mahmoud
Asle mohamadi zadeh
محمود
اصل محمدی زاده
asle2012@gmail.com