Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
000
000
000
000
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fa
jalali
1401
1
1
gregorian
2022
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online
1
fulltext
fa
تأثیر 6 هفته تمرین استقامتی و مصرف امپاگلیفلوزین بر شاخصهای التهابی و ارتباط آن با ساختار و عملکرد قلب رتهای نر دیابتی
Effect of a Six-Week Endurance Exercise and Empagliflozin Consumption on Some Structural and Functional Indices of the Heart in Male Diabetic Rats
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:107%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">مقدمه:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> هدف از پژوهش حاضر بررسی تأثیر هشت هفته تمرین استقامتی و مصرف امپاگلیفلوزین بر شاخصهای التهابی و ارتباط آنها با ساختار و عملکرد قلب در رتهای نر دیابتی است.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">روشها: </span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">40 سر موش نر نژاد ویستار بهصورت تصادفی به پنج گروه کنترل سالم، کنترل دیابتی، دیابتی+امپاگلیفلوزین، دیابتی+تمرین استقامتی و دیابتی+تمرین استقامتی+امپاگلیفلوزین تقسیم شدند. گروهها پس از انجام پروتکل تمرینی و دریافت دارو، بیهوش و عملکرد قلبی و شاخصهای </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TNF-</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">α</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TGF-</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">β</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> با آزمونهای آماری آنوای یکطرفه و همبستگی پیرسون بررسی شد.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">تفاوت معنیدار در ضخامت پایان سیستولی بطن چپ (011/0 </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P=</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">)، حجم پایان سیستولی بطن چپ (008/0 </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P=</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">)، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TNF-</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">α</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> (014/0 </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P=</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">) و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TGF-</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">β</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">(001/0 </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P=</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">) بین گروههای پژوهش مشاهده شد. ارتباط منفی معنیداری بین </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TGF-</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">β</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> با وزن بدن، درصد کوتاه شدن الیاف قلب و کسر تزریقی</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> و ارتباط مثبت معنیدار با</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> سطوح گلوکز، ضخامت پایان سیستولی بطن چپ و حجم پایان سیستولی بطن چپ </span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">نشان داد. بهعلاوه، ارتباط منفی معنیداری بین </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TGF-</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">β</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> با کسر تزریقی </span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">مشاهده شد (05/0</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P≤</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">). </span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">نتیجه‏ گیری: </span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">بهنظر میرسد تمرین هوازی خارج از تأثیر مضاعف امپاگلیفلوزین موجب بهبود وضعیت التهابی، ساختار و عملکرد بافت قلب دیابتی میشود.</span></span><b><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"></span></span></b></span></span></span></span></span>
<span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Background:</span></b><span new="" roman="" style="font-family:" times=""> The aim of this study was to evaluate the effect of eight weeks of endurance training and Empagliflozin consumption on inflammatory markers and their relationship with heart structure and function of diabetic male Rats.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Methods</span></b><span new="" roman="" style="font-family:" times="">: 40 male Wistar rats were randomly divided into five groups: healthy control, diabetic control, diabetic + empagliflozin, diabetic + endurance training and diabetic + endurance training + empagliflozin. The groups were anesthetized and their cardiac function and TNF-α and TGF-β indices were evaluated by one-way ANOVA and Pearson correlation tests after performing the training protocol and receiving medication</span><span new="" roman="" style="font-family:" times="">.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><span new="" roman="" style="font-family:" times=""> There were significant differences in left ventricular end systolic thickness (P = 0.011), left ventricular end systolic volume (P = 0.008), TNF-α (P = 0.014) and TGF-β (P = 0.001) was observed between the research groups. Also, there was a significant negative relationship between TGF-β with body weight, heart fiber shortening percentage and injection fraction and a significant positive relationship with glucose levels, left ventricular end systolic thickness and left ventricular end systolic volume. In addition, a significant negative correlation was observed between TGF-β and the injection fraction (P≤0.05).</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b> <span new="" roman="" style="font-family:" times="">Aerobic exercise seems to improve the inflammatory status, structure and function of diabetic heart tissue beyond the dual effect of Empagliflozin.</span><span style="font-family:"Times New Roman",serif"></span></span></span></span></span>
تمرین هوازی, امپاگلیفلوزین, التهاب, قلب, دیابت
Aerobic Exercise, Empagliflozin, Inflammation, Heart, Diabetes
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http://ijdld.tums.ac.ir/browse.php?a_code=A-10-1409-2&slc_lang=fa&sid=1
Eftekhar
Mohammadi
افتخار
محمدی