Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
000
000
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fa
jalali
1401
8
1
gregorian
2022
11
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online
1
fulltext
fa
مقایسهی پاسخMR-proADM ، NO و HOMA-IR به یک جلسه فعالیت ورزشی زیر بیشینه در آزمودنیهای ورزشکار و غیر ورزشکار
Comparison of Mr-Proadm, No and Homa-Ir Responses to A Session of Submaximal Exercise in Athletes and Non-Athletes
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="tab-stops:center 167.75pt left 210.55pt center 229.9pt"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">مقدمه:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">آدرنومدولین(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">ADM</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">)یک پپتید چند عملکردی است که در طیف گستردهای از فرآیندهای فیزیولوژیکی و عملکرد قلبی-عروقی نقش دارد. هدف از پژوهش حاضر مقایسهی تأثیر فعالیت جسمانی (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">(PA</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> بر سطوح </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">ADM</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">، نیتریکاکساید (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">NO</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">) و میزان مقاومت به انسولین (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">HOMA-IR</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">) در افراد ورزشکار و غیر ورزشکار بود.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:center 167.75pt left 210.55pt center 229.9pt"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">روشها:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">12 ورزشکار و11 غیر ورزشکار دراین مطالعهی نیمهتجربی شرکت کردند. شرکتکنندگان پژوهش با روش نمونهگیری در دسترس انتخاب شدند. تمرین تردمیل بیشینه (برنامهی بروس) در هر دو گروه انجام شد. نمونههای خونی قبل و پس از انجام جلسه تمرین جهت بررسی متغیرها جمعآوری گردید. دادهها با استفاده از تحلیل کوواریانس یکطرفه، تی زوجی، تی مستقل و همبستگی پیرسون و در سطح معنیداری </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus"">05/0</span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif">P<u><</u></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> تجزیه و تحلیل شدند.</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">یافتهها:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> نتایج نشان داد که پس ازیک وهله فعالیت ورزشی زیربیشینه، شاخص </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">HOMA-IR</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> در گروه غیر ورزشکار کاهش </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus"">(034/0 </span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif">P=</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus"">) </span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">و مقادیر </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">NO</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> هر دو گروه ورزشکار و غیر ورزشکار افزایشیافت </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus"">(001/0 </span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif">P=</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus"">، 002/0 </span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif">P=</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus"">) </span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">واین افزایش در گروه ورزشکار بیشتر بود. همچنین در مقادیر </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">ADM</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> سرم در گروه غیر ورزشکار </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus"">(001/0 </span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif">P=</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus"">) </span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">پس از اتمام وهلهی تمرین افزایش مشاهده شد.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222">نتیجهگیری:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> یک جلسه فعالیت جسمانی، احتمالاً با افزایش سطوح </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">ADM</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">NO</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> میتواند منجر به اتساع عروقی بهتر و بهبود عملکرد اندوتلیال و همچنین بهبود مقاومت به انسولین در افراد غیرفعال شود. از آنجا که در افراد ورزشکار تنها سطوح </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">NO</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> پس از پایان فعالیت افزایش یافت، بهنظر میرسد </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:#222222">PA</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:#222222"> بر بهبود عملکرد اندوتلیال افرادغیرفعال تأثیر بیشتری دارد.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="tab-stops:center 167.75pt left 210.55pt center 229.9pt"><span style="text-autospace:none"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif">Background:</span></b> <span style="font-family:"Times New Roman",serif">Adrenomodoline (ADM) is a multifunctional peptide involved in a wide range of physiological processes and cardiovascular function.</span><span style="background:white"><span style="font-family:"Times New Roman",serif"> The <em>purpose</em> of the <em>present study</em> was to compare the effect of physical activity on ADM and nitric oxide (NO) levels and insulin resistance in athletes and non-athletes.</span></span><span dir="RTL" lang="AR-SA" style="font-size:14.0pt"><span style="background:white"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:center 167.75pt left 210.55pt center 229.9pt"><span style="text-autospace:none"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><span style="font-family:"Times New Roman",serif">Material and </span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:center 167.75pt left 210.55pt center 229.9pt"><span style="text-autospace:none"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif">Methods:</span></b> <span style="font-family:"Times New Roman",serif">12 athletes and 11 non-athletes participated in this quasi-experimental study.</span><span style="background:white"><span style="font-family:"Times New Roman",serif"> Study <em>participants </em></span></span><span style="font-family:"Times New Roman",serif">were selected by convenience sampling.</span> <span style="font-family:"Times New Roman",serif"> Both groups performed the Bruce protocol. Blood samples were collected before and after the training session to study the variables. Data were analyzed using one-way analysis of covariance, paired t-test, independent t-test and Pearson correlation.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:center 167.75pt left 210.55pt center 229.9pt"><span style="text-autospace:none"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif">Results:</span></b><span style="font-family:"Times New Roman",serif"> The results showed that after one session of submaximal exercise activity, HOMA-IR index decreased in non-athlete group (P = 0.034) and NO values increased in both athlete and non-athlete groups (P = 0.001, P = 0.002) and this increase was greater in the athlete group. Also, serum ADM levels were increased in the non-athlete group (P = 0.001) after the training session.</span><span dir="RTL" lang="AR-SA" style="font-size:14.0pt"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:center 167.75pt left 210.55pt center 229.9pt"><span style="text-autospace:none"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif">Conclusion:</span></b><span style="font-family:"Times New Roman",serif"> The single session of physical activity with increasing ADM and NO levels, can lead to better vasodilation and improved endothelial function as well as improved insulin resistance in inactive individuals. Since in athletes, only NO levels increased after the end of the activity, it seems that PA has a greater effect on improving the endothelial function of inactive people.</span></span></span></span></span></span>
آدرنومدولین, نیتریکاکساید, مقاومت به انسولین, تمرین, عملکرد اندوتلیال
Adrenomedullin, Nitric oxide, Insulin resistance, Exercise, Endothelial function
234
244
http://ijdld.tums.ac.ir/browse.php?a_code=A-10-1784-1&slc_lang=fa&sid=1
Manijeh
Namjoo
منیژه
نامجو