Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
000
000
000
000
000
fa
jalali
1401
9
1
gregorian
2022
12
1
22
5
online
1
fulltext
fa
تأثیر ترکیب تمرین هوازی و ژل رویال بر بیان سایتوکاینهای پیشالتهابی بافت کبد موشهای چاق
The Effect of Combining Aerobic Exercise and Royal Jelly on the Expression of Pro-Inflammatory Cytokines in Liver Tissue of Obese Rats
عمومى
General
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:107%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">مقدمه: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">التهاب نقش مهمی در افزایش آسیب سلولهای کبدی و فیبروز کبد ایفا میکند. در سالهای اخیر نقش محافظتی فعالیت ورزشی و ژل رویال (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">RJ</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">) برای اختلالات متابولیک و التهابی پیشنهاد شده است. هدف از مطالعهی حاضر بررسی اثرات تمرین هوازی (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">AT</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">) و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">RJ</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> بر نشانگرهای پیشالتهابی در موش صحرایی مدل رژیم غذایی پُرچرب (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFD</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">) بود.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">روشها:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> در این مطالعهی تجربی، 45 موش صحرایی نر بهطور تصادفی به پنج گروه (هر گروه: 9=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">n</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">): رژیم غذایی نرمال (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">ND</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">)، رژیم غذایی پُرچرب (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFD</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">)، رژیم غذایی پُرچرب+تمرین (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFDT</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">)، رژیم غذایی پُرچرب+ژل رویال (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFDRJ</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">) و رژیم غذایی پُرچرب+تمرین+ژل رویال (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFDTRJ</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">) تقسیم شدند. گروههای مکمل، طی دورهی مداخلهی روزانه 100 میلیگرم </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">RJ</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> (به ازای هر کیلوگرم وزن بدن) رقیق شده در آب مقطر را بهصورت خوراکی دریافت کردند. برنامهی تمرین هوازی شامل دویدن روی تردمیل با شدت 60-50 درصد اکسیژن مصرفی (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">VO2max</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">)، پنج روز در هفته بهمدت هشت هفته بود.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">یافتهها: </span></span></span></b><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFD</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> باعث افزایش </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">NF-κB</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> (006/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">p</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">)، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">TNF-α</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> (006/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">p</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">) و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">IL-1β</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> (0001/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">p</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">) کبدی شد. </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">AT</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">RJ</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> و همچنین ترکیب </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">AT</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> با </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">RJ</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> باعث کاهش </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">NF-κB</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">TNF-α</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">IL-1β</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> شد (05/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">p≤</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">). کاهش </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">NF-κB</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">TNF-α</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">IL-1β</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> در گروه </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFDTRJ</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> نسبت به گروه </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFDT</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">HFDRJ</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> معنیدار بود (05/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman",serif"><span style="color:black">p≤</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">).</span></span></span></span></span></span></span></span><br>
<span style="font-size:14pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">نتیجهگیری</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">: </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">ترکیب </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black">AT</span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black">RJ</span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> ممکن است با کاهش بیان </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black">NF-κB</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black">TNF-α</span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black">IL-1β</span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> باعث کاهش شاخصهای التهابی شده و استئاتوز کبدی ناشی از </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black">HFD</span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="color:black"> را بهبود بخشد.</span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif"><span style="color:black">Background: </span></span></b><span style="font-family:"Times New Roman",serif"><span style="color:black">Inflammation plays a critical role in the promotion of hepatocyte damage and liver fibrosis. In recent years the protective role of exercise and royal jelly (RJ), has been suggested for metabolic and inflammatory disorders. In this study, we aimed to evaluate the effects of aerobic training (AT) and RJ on pro-inflammatory markers in a rat's model of a high-fat diet (HFD).</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif"><span style="color:black">Methods: </span></span></b><span style="font-family:"Times New Roman",serif"><span style="color:black">In this experimental study, 45 male rats were randomly divided into five groups (Each group: n=9): Normal Diet (ND), High-Fat Diet (HFD), High-Fat Diet +Training (HFDT), High-Fat Diet + Royal Jelly (HFDRJ), and High-Fat Diet +Training + Royal Jelly (HFDTRJ). The supplement groups received 100 mg of royal jelly (kg/body weight) diluted in distilled water orally during the intervention period. The aerobic exercise program included treadmill running with an intensity of 50-60% oxygen consumption (VO2max), 5 days/week for 8 weeks.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif"><span style="color:black">Results:</span></span></b><span style="font-family:"Times New Roman",serif"><span style="color:black"> HFD increased hepatic NF-κB (p=0.006), TNF-α (p=0.0001) and IL-1β (p=0.0001). AT, RJ as well as the combination of AT with RJ decreased NF-κB, TNF-α and IL-1β (p≤0.05). Decrease in NF-κB, TNF-α and IL-1β were significant in HFDTRJ group compared to HFDT and HFDRJ groups (p≤0.05).</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif"><span style="color:black">Conclusion:</span></span></b><span style="font-family:"Times New Roman",serif"><span style="color:black"> The combination of AT and RJ may decrease inflammatory markers and improve HFD-induced hepatic steatosis by reducing the expression of NF-κB, TNF-α, and IL-1β.</span></span></span></span></span></span>
فعالیت ورزشی, ژل رویال, التهاب, کبد, چاقی
Exercise, Royal Jelly, Inflammation, Liver, Obesity
282
293
http://ijdld.tums.ac.ir/browse.php?a_code=A-10-378-5&slc_lang=fa&sid=1
Mahdieh
Ghasemi
مهدیه
قاسمی