Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
000
000
000
000
000
fa
jalali
1402
2
1
gregorian
2023
5
1
23
2
online
1
fulltext
fa
تأثیر تمرین ورزشی بر سطوح CTRP3 در افراد بزرگسال با اختلالات متابولیکی: مرور نظاممند با فراتحلیل
The Effect of Exercise Training on CTRP3 Levels in Adults with Metabolic Disorders: A Systematic Review with Meta-Analysis
عمومى
General
مروري
Review
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">مقدمه:</span></span></span></b> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">CTRP3</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"> بهعنوان هورمون ضد التهابی مشتق شده از بافت چربی شناخته شده است که منجر به بهبود مقاومت به انسولین میشود. با این وجود، آثار تمرین ورزشی بر این آدیپوکاین درک نشده است. از اینرو، هدف فراتحلیل حاضر بررسی تأثیر تمرین ورزشی بر مقادیر گردش خونی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">CTRP3</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"> در افراد با اختلالات متابولیکی بود.</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">روشها:</span></span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">جستجوی جامع در پایگاههای اطلاعاتی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">pubmed</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">web of science</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">تا اکتبر 2022 (مهرماه 1401) با استفاده از کلید واژههای «تمرین ورزشی» و «</span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">CTRP3</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">» انجام شد. معیارهای ورود به تحقیق حاضر شامل دارا بودن مطالعات انسانی با اختلالات متابولیکی، مداخلۀ تمرین ورزشی و مقادیر گردش خونی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">CTRP3</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"> بود. تفاوت میانگین استاندارد شده (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">SMD</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">) و فاصلۀ اطمینان 95 درصد با استفاده از روش تصادفی محاسبه شد.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">یافتهها:</span></span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">در مجموع 9 مطالعه شامل 12 مداخلۀ ورزشی و 365 آزمودنی مبتلا به اختلالات متابولیکی وارد فراتحلیل شدند. نتایج تحلیل دادهها نشان داد که تمرین ورزشی منجر به افزایش معنیدار </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">CTRP3</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> شد [03/0</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">=</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">، (10/1 الی 03/</span></span><span lang="AR-SA" style="font-size:10.0pt"><span b="" lotus="" style="font-family:">0</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">CI</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">: </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">) 57/0]. همچنین، نتایج آزمون </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">I<sup>2</sup></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> ناهمگونی بالا و معنیداری (001/0</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">, </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">=</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">59/84</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">I<sup>2</sup></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">=</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">) و نتایج آزمون </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Egger</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"> سوگیری معنیداری انتشار (001/0</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">=</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">) را نشان دادند.</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">نتیجهگیری: </span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">تمرین ورزشی با اندازه اثر متوسط منجر به افزایش معنیدار مقادیر گردش خونی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">CTRP3</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"> در افراد با بیماریهای متابولیکی و قلبی عروقی میشود که ممکن است یک میانجی برای اثرات مفید تمرینات ورزشی باشد.</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Background:</span></b><span new="" roman="" style="font-family:" times=""> <span style="background:white">CTRP3 is known to be an adipose tissue-derived anti-inflammatory hormone that leads to improved insulin resistance. However, the effects of exercise training on this adipokine are poorly understood. Therefore, the aim of the present meta-analysis was to investigate the effect of exercise training on circulating CTRP3 levels in adults with metabolic disorders.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.65pt">Methods:</span></span></b> <span new="" roman="" style="font-family:" times="">A comprehensive search was conducted in PubMed and Web of Science databases through October 2022 using the keywords "exercise training" and "CTRP3". The inclusion criteria for the current research included human studies with metabolic disorders, exercise training intervention, and circulating CTRP3 values. Standardized mean difference (SMD) and 95% confidence interval were calculated using random method.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><span new="" roman="" style="font-family:" times=""> A total of 9 studies including 12 intervention arms and 365 participants with metabolic disorders were included in the meta-analysis. The results of data analysis showed that exercise training led to a significant increase in CTRP3 [0.57, (CI: 1.10 to 0.03) P=0.03]. Also, the results of the I2 test showed that there is a high and significant heterogeneity (I2 =84.59, P=0.001) and the results of the Egger test showed a significant publication bias (P=0.001).</span><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b><span new="" roman="" style="font-family:" times=""> Exercise training with a moderate effect size leads to a significant increase in circulating CTRP3 levels in individual with metabolic and cardiovascular diseases, which may be a mediator of the beneficial effects of exercise training.</span></span></span></span></span>
تمرین ورزشی, CTRP3, اختلال متابولیکی
Exercise Training, CTRP3, Metabolic Disorder
68
79
http://ijdld.tums.ac.ir/browse.php?a_code=A-10-381-2&slc_lang=fa&sid=1
Mousa
Khalafi
موسی
خلفی
mousa.khalafi@kashanu.ac.ir