Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
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fa
jalali
1402
12
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gregorian
2024
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online
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fulltext
fa
تأثیر هشت هفته تمرینهای تناوبی با شدت بالا و مصرف عصارۀ برگ لوکوات بر سطوح سرمی TNF-α و اینترلوکین 18 در مردان چاق مبتلا به کبد چرب غیرالکلی
Effect of High-Intensity Interval Training and Loquat Leaf Extract Consumption on the Serum Levels of TNF-Α and Interleukin 18 in Obese Men with Non-Alcoholic Fatty Liver Disease
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">مقدمه:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black"> تمرین</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">های تناوبی با شدت بالا</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">(</span></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">HIIT</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">)</span></span></span> <span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">و مصرف عصارههای گیاهی احتمالاً اثرات سودمندی بر شاخص</span></span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:"><span style="color:black"></span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">های التهابی دارد. هدف از مطالعۀ حاضر تأثیر هشت هفته تمرین</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="color:black"></span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">های تناوبی شدید و مصرف عصارۀ برگ لوکوات بر سطوح سرمی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">TNF-α</span></span></span><span style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black"> و اینترلوکین 18 در مردان چاق مبتلا به کبد چرب غیرالکلی بود.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">روشها:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">در این مطالعۀ نیمهتجربی، 40 مرد مبتلا به کبد چرب غیرالکلی دارای نمایۀ تودۀ بدنی (82/1</span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:">±</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">92/33) بهطور تصادفی به چهار گروه کنترل، تمرین، عصاره، عصاره+تمرین، هر گروه 10 نفر تقسیم شدند. تمرین</span></span><span dir="LTR" style="font-size:12.0pt"></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">ها بهمدت 8 هفته و سه جلسه در هفته بهمدت 60 دقیقه با شدت بین 80-95 درصد ضربان قلب ذخیره انجام شد. بهمدت هشت هفته، روزی دو عدد کپسول250 میلیگرمی عصارۀ برگ لوکوات نیز تجویز شد. از آزمون تی زوجی و تحلیل کوواریانس استفاده شد.</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="color:black">یافتهها:</span></span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="color:black"> کاهش معنادار سطوح </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="color:black">TNF-α</span></span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="color:black">(3/15%) و اینترلوکین 18 (9/14%) در گروه تمرین+عصاره مشاهده شد (05/0</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="color:black">≤</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="color:black">). اختلاف معناداری در سطوح </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="color:black">TNF-α</span></span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="color:black">(001/0 =</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="color:black">) و اینترلوکین 18 (001/0 =</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="color:black">) بین گروهها بهدست آمد که این تغییرات در گروه عصاره+تمرین نسبت به گروههای تمرین و عصاره بزرگتر است.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black">نتیجهگیری:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">بهنظر میرسد انجام تمرین</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">ها تناوبی شدید همراه با مصرف عصارۀ برگ لوکوات قادر به بهبود شاخصهای </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TNF-α</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:">و اینترلوکین 18 مرتبط با کبد چرب در افراد مبتلا به بیماری کبد چرب غیرالکلی خواهد شد. با این حال تأیید این فرضیه نیازمند پژوهشهای بیشتر است.</span></span><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><span lang="FA" style="font-size:12.0pt"><span b="" lotus="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="line-height:92%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Background:</span></b><span new="" roman="" style="font-family:" times=""> Interval exercises with high intensity and consumption of plant extracts probably have beneficial effects on inflammatory indicators. The aim of this study was to investigate the effect of eight weeks of High-Intensity Interval Training (HIIT) and the consumption of Loquat leaf extract on the serum levels of TNF-α and interleukin-18 in obese men with non-alcoholic fatty liver disease.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b><span new="" roman="" style="font-family:" times=""> In this semi-experimental study, forty men with non-alcoholic fatty liver disease with body mass index (33.92 ± 1.82) with informed written consent were randomly selected and assigned into four groups: control, training, Extract, Extract + training (Each group of 10 people). Exercises were performed for eight weeks and three sessions per week for 60 minutes with intensity between 80-95% of the reserve heart rate. Two capsules of 250 mg of Loquat leaf extract were also prescribed daily. Paired t-test and analysis of covariance were used.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><span new="" roman="" style="font-family:" times=""> A significant decrease in the levels of TNF-α (15.3%) and interleukin 18 (14.9%) was observed in the training + extract group (P<0.05). A significant difference was observed in the levels of TNF-α (P=0.001) and interlock 18 (P=0.001) between the groups, and these changes were more significant in the Extract + training group than in the training and extract groups. </span></span></span></span><br>
<b><span style="font-size:11.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Conclusions:</span></span></span></b><span style="font-size:11pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> It is concluded that performing intense intermittent training along with Loquat leaf extract will be able to improve TNF-α and interleukin 18 indices related to fatty liver in people with non-alcoholic fatty liver disease. However, confirmation of this hypothesis requires more research.</span></span></span>
تمرینهای اینتروال شدید, لوکوات, اینترلوکین 18, TNF-α, کبد چرب
Interval training, Loquat, Interleukin 18, TNF-α, Fatty liver
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67
http://ijdld.tums.ac.ir/browse.php?a_code=A-10-1954-1&slc_lang=fa&sid=1
Setareh
Moradi Vafa
ستاره
مرادی وفا