Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
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2345-4008
2345-4016
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jalali
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2024
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یک دوره تمرین مقاومتی و استقامتی همراه با مصرف اورسولیک اسید بر سطوح فتوئین-A و B بافت کبدی رتهای نر سالمند دیابتی
Comparison of the Effect of a Course of Resistance and Endurance Training with Ursolic Acid Consumption on the Levels of Fetoin-A and B in the Liver Tissue of Elderly Male Diabetic Rats
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">مقدمه:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> فتوئین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">A</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">- و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">B</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> هپاتوکاین</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"Cambria","serif""><span style="letter-spacing:-.2pt"></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">های هستند که با دیابت نوع دو ارتباط دارند. هدف پژوهش حاضر مقایسۀ تأثیر یک دوره تمرین مقاومتی و استقامتی همراه با دریافت اورسولیک اسید بر سطوح فتوئین-</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">A</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> و -</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">B</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> بافت کبدی رتهای سالمند دیابتی شده با </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">HFD-STZ</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> بود.</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">روشها:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> 56 سر رت 21 ماهه دیابتیشده بهطور تصادفی به هفت گروه مساوی کنترل (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">C</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">)، مکمل اورسولیک اسید (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">)، مکمل+تمرین مقاومتی ((</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+R</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">، مکمل+تمرین استقامتی (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+E</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">)، تمرین مقاومتی (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">R</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">)، تمرین استقامتی (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">E</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">) و گروه شم (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">D</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">) تقسیم شدند. پروتکل تمرین مقاومتی با شدت 60% </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">MVCC</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">، 20-14 مرتبه بالارفتن از نردبان با یک دقیقه استراحت در بین هر تلاش و تمرین استقامتی شامل دویدن روی نوارگردان با شدت بالا 60-75% و شدت پایین 30-40% سرعت بیشینه پنج روز در هفته و بهمدت هشت هفته بود. گروههای دریافتکنندۀ مکمل، میزان500 میلیگرم بر کیلوگرم </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> در ترکیب با غذای پُرچرب دریافت کردند.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">یافتهها:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> میزان فتوئین-</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">A</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> در گروه </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">،</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">E </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+E</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> کاهش معنیداری داشت (05/0</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">≥</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">) و تنها در گروه </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">R</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+R</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">، کاهش معنیدار نبود. همچنین میزان فتوئین-</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">B</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> در موش</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"Cambria","serif""><span style="letter-spacing:-.2pt"></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">های دیابتی در گروه </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">،</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">E </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">R</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+E</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> کاهش معنیداری داشت (05/0</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">≥</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">) و تنها در گروه تمرین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+R</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> تغییرات معنیدار نبود. میزان فتوئین -</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">A</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> و فتوئین -</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">B</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> در بین گروه </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">E</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> با </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">R</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+R</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> با </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+E</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> تفاوت معنیداری داشت (05/0</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">≥</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">) که بیشترین کاهش در گروه </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA+E</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> بود.<i></i></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">نتیجهگیری: </span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">با توجه به آثار مفید تمرینات و مکمل </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> بر هپاتوکین</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Cambria","serif""><span style="letter-spacing:-.2pt"></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt">ها بهنظر میرسد ارائۀ همزمان دو مداخلۀ تمرین ورزشی و مکمل </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-.2pt">UA</span></span></span><span style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.2pt"> تأثیر درمانی مؤثرتری بر هپاتوکینهای کبدی دیابتیها داشته باشد.</span></span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><b><span style="font-family:"Times New Roman","serif"">Background:</span></b><span style="font-family:"Times New Roman","serif""> <span style="background:white">Fetoin-A and -B are hepatokines that are related to type 2 diabetes. The aim of the present study was to investigate the effect of a period of resistance and endurance training with Ursolic acid consumption on the levels of Fetoin-A and -B in the liver tissue of elderly diabetics.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><b><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:.65pt">Methods:</span></span></b> <span style="font-family:"Times New Roman","serif"">Fifty six 21-month-old male diabetic rats were randomly divided into seven equal groups of control (C), Ursolic acid supplement (UA), supplement+resistance exercise (UA+R), supplement+endurance exercise (UA+E), Resistance training (R), endurance training (E) and sham group (D). Resistance training protocol with intensity of 60% MVCC, 14-20 times of ladder climbing with one minute rest between each effort and endurance training including running on Treadmill at high intensity 60-75% and low intensity 30-40% of maximum speed for five days per week for eight weeks. Supplemented groups received 500 mg/kg UA in combination with a high-fat meal.</span><sup><span style="font-size:12.0pt"><span style="letter-spacing:-.2pt"></span></span></sup></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><b><span style="font-family:"Times New Roman","serif"">Results:</span></b><span style="font-family:"Times New Roman","serif""> Fetoin-A level was significantly decreased in UA, E, UA+E groups (p≤0.05) and only in R and UA+R groups, there was no significant decrease. Also, The amount of Fetoin-B in diabetic rats in the UA, E, R, UA+E groups decreased significantly (p≤0.05) and only in the UA+R training group there were no significant changes. The amount of Fetoin-A and Fetoin-B was significantly different between E and R and UA+R and UA+E groups (p≤0.05), which the largest decrease was in the UA+E group.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><b><span style="font-family:"Times New Roman","serif"">Conclusion:</span></b><span style="font-family:"Times New Roman","serif""> Considering the beneficial </span><span style="background:white"><span style="font-family:"Times New Roman","serif"">effects of exercise training as well as UA supplementation on hepatokines, it seems that the simultaneous application of two interventions of exercise training and UA supplementation has a more therapeutic effect on the hepatic hepatokines of diabetics.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="line-height:107%"><span style="font-family:Calibri,"sans-serif""><span style="font-family:"Times New Roman","serif""></span></span></span></span></span>
فتوئین A, فتوئین B, اورسولیک اسید, تمرین ورزشی
Fetuin A, Fetuin B, Ursolic Acid, Exercise
398
408
http://ijdld.tums.ac.ir/browse.php?a_code=A-10-2029-1&slc_lang=fa&sid=1
Laleh
Bagheri
لاله
باقری