Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
000
000
000
000
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fa
jalali
1403
3
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gregorian
2024
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online
1
fulltext
fa
اثر ده هفته تمرین هوازی و مقاومتی بر سطح سرمی پنتراکسین-3، گرملین-1 و مقاومت به انسولین در مردان مبتلا به دیابت نوع دو
The Effect of Ten Weeks of Aerobic and Resistance Training on Serum Level of Pentraxin-3, Gremlin-1 and Insulin Resistance in Men with Type-2 Diabetes
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">مقدمه:</span></span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">بیماری دیابت شیرین نوع دو همانند سایر بیماری</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span cambria="" style="font-family:"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">های التهابی، موجب تغییر در سطوح نشانگرهای ضدالتهابی مانند پنتراکسین-3 و پیش</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span cambria="" style="font-family:"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">التهابی مثل گرملین-1 می</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span cambria="" style="font-family:"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">شود. هدف پژوهش حاضر مقایسۀ آثار 10 هفته تمرین هوازی و مقاومتی بر سطوح سرمی پنتراکسین-3، گرملین-1 و مقاومت به انسولین در مردان مبتلا به دیابت نوع دو بود.</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">روشها:</span></span></span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">در این مطالعۀ نیمه</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span cambria="" style="font-family:"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">تجربی، 29 مرد مبتلا به دیابت نوع دو در دامنۀ سنی 25 تا 40 سال انتخاب و به روش تصادفی به سه گروه تمرین هوازی، تمرین مقاومتی و کنترل تقسیم شدند. برنامۀ تمرین گروه هوازی با شدت 55 تا 75 درصد ضربان قلب بیشینه و مقاومتی با شدت 55 تا 75 درصد یک تکرار بیشینه طی 10 هفته و سه جلسه در هفته اجرا گردید. پیش و پس از دورۀ مداخله سطوح سرمی پنتراکسین-3، گرملین-1 اندازه</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span cambria="" style="font-family:"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">گیری و شاخص مقاومت به انسولین نیز محاسبه شد.</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:dotted 0cm"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">یافتهها: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">در هردو گروه تمرین هوازی (039/0 =</span></span></span><span dir="LTR" lang="IT" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">) و مقاومتی (019/0 =</span></span></span><span dir="LTR" lang="IT" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">) سطح </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">سرمی </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">پنتراکسین-3</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">در مقایسه با گروه کنترل افزایش معناداری داشت؛ اما بین دو گروه تفاوتی دیده نشد (703/0 =</span></span></span><span dir="LTR" lang="IT" new="" roman="" style="font-family:" times="">P</span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">). همچنین، سطوح سرمی گرملین- 1 و مقاومت به انسولین گروههای تمرین هوازی (بهترتیب؛ 022/0 =</span></span></span><span dir="LTR" lang="IT" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">و 040/0 =</span></span></span><span dir="LTR" lang="IT" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">) و مقاومتی (بهترتیب؛ 037/0 =</span></span></span><span dir="LTR" lang="IT" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">و 031/0 =</span></span></span><span dir="LTR" lang="IT" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">) نسبت به گروه کنترل کاهش معناداری را نشان داد؛ گرچه بین گروههای تمرینی تفاوتی وجود نداشت (بهترتیب؛ 815/0 =</span></span></span><span dir="LTR" lang="IT" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">و 659/0 =</span></span></span><span dir="LTR" lang="IT" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">).</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">نتیجهگیری:</span></span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt"> نتایج این پژوهش نشان داد که هر دو نوع تمرین هوازی و مقاومتی دارای آثار مشابهی در بهبود نشانگرهای التهابی و مقاومت به انسولین بیماران مبتلا به دیابت نوع دو هستند.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:right 0cm"><span sans-serif="" style="font-family:Calibri,"><b><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""> <span style="background:white">Type 2 diabetes mellitus, like other inflammatory diseases, causes a change in the levels of pro-inflammatory (such as gremlin-1) and anti-inflammatory (such as pentraxin-3) markers. The aim of the present study was to compare the effects of 10 weeks of aerobic and resistance training on serum levels of pentraxin-3, gremlin-1 and insulin resistance in men with type 2 diabetes.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:right 0cm"><span sans-serif="" style="font-family:Calibri,"><b><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.65pt">Methods:</span></span></span></b> <span new="" roman="" style="font-family:" times="">In this semi-experimental study, 29 men with type 2 diabetes in the age range of 25-45 years were selected and randomly divided into three groups: aerobic training, resistance training and control. Aerobic training program with an intensity of 55-75% of the maximum heart rate and resistance training with an intensity of 55-75% of one repetition maximum was implemented during 10 weeks and 3 sessions per week. Before and after the intervention period, serum levels of pentraxin-3, gremlin-1 were measured and also insulin resistance index was calculated.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:right 0cm"><span sans-serif="" style="font-family:Calibri,"><b><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""> In both aerobic (P= 0.039) and resistance (P= 0.019) training groups, pentraxin-3 serum level increased significantly compared to the control group; but there was no difference between the two groups (P= 0.703). Also, serum levels of gremlin-1 and insulin resistance of the aerobic (P= 0.022 and P= 0.040, respectively) and resistance (P= 0.037 and P= 0.031, respectively) training groups showed a significant decrease compared to the control group; Although there was no difference between the training groups (P= 0.815 and P= 0.659, respectively).</span></span><span dir="RTL" lang="FA" style="font-size:14.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span sans-serif="" style="font-family:Calibri,"><b><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""> This findings demonstrate that both types of aerobic and resistance training are equally effective in improving inflammatory markers and insulin resistance in type 2 diabetes patients.</span></span></span></span></span>
تمرین هوازی, تمرین مقاومتی, پنتراکسین-3, گرملین-1, دیابت نوع دو
Aerobic Training, Resis Tance Training, Pentraxin-3, Gremlin-1, Type 2 Diabetes
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http://ijdld.tums.ac.ir/browse.php?a_code=A-10-2034-1&slc_lang=fa&sid=1
Esfandiar
Jahanfar
اسفندیار
جهانفر