Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
000
000
000
000
000
fa
jalali
1402
12
1
gregorian
2024
3
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24
1
online
1
fulltext
fa
مقایسۀ اثر رژیم غذایی کمکالری و تمرین ورزشی بر لپتین و آدیپونکتین در افراد میانسال و سالمند دارای اضافه وزن و چاق: یک مرور نظاممند و فراتحلیل
Comparison of the Effect of Low-Calorie Diet and Exercise on Leptin and Adiponectin in Middle-Aged and Elderly Adults with Overweight and Obesity: A Systematic Review and Meta-Analysis
تخصصي
Special
مروري
Review
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">مقدمه:</span></span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">لپتین و آدیپونکتین، آدیپوکینهایی هستند که توسط سلولهای چربی تولید میشوند و در بیماری چاقی نقش مهمی دارند. هدف مطالعۀ حاضر بررسی مقایسه اثر رژیم غذایی کمکالری (</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">LCD</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">) و تمرین ورزشی (</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">Exe</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"><span style="letter-spacing:-.2pt">) بر لپتین و آدیپونکتین در میانسالان و سالمندان دارای اضافه وزن و چاق بود.</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">روشها:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> جستجوی سیستماتیک در پایگاه</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span cambria="" style="font-family:"></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">های اطلاعاتی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">PubMed</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Web</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">of</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Science</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">SID</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Magiran</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Google</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">scholar</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> برای مقالات انگلیسی و فارسی منتشر شده تا مرداد ماه سال 1402 انجام شد. اندازه اثر و فاصله اطمینان 95 درصد با استفاده از مدل اثر تصادفی محاسبه شد.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">یافتهها:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">نتایج 25 مطالعه با 2063 میانسال و سالمند دارای اضافه وزن و چاق نشان داد که ترکیب تمرین ورزشی و رژیم غذایی نسبت به </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Exe</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> سبب کاهش معنادار لپتین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">]</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">001/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">= </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> ،4/0- =</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">[</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">SMD</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">و</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> افزایش معنادار آدیپونکتین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">]</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">02/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">= </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">، 17/0 =</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">[</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">SMD</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">در</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> میانسالان و سالمندان دارای اضافهوزن و چاق شد. در مقابل </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">LCD</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> نسبت به </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">Exe</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> سبب تغییر معنادار لپتین سرمی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">]</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">1/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">= </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> ،16/0- =</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">[</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">SMD</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">و آدیپونکتین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">]</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">7/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">= </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">، 05/0 =</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">[</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">SMD</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">در</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> میانسالان و سالمندان دارای اضافهوزن و چاق نشد. همچنین ترکیب تمرین ورزشی و رژیم غذایی نسبت به </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">LCD</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> سبب تغییر معنادار لپتین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">]</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">2/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">= </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">، 11/0- =</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">[</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">SMD</span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">و</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> آدیپونکتین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">]</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">8/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">= </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">، 02/0 =</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span gothic="" style="font-family:" yu="">[</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span new="" roman="" style="font-family:" times="">SMD</span></span></span> <span lang="FA" style="font-size:10.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">در</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:"> میانسالان و سالمندان دارای اضافهوزن و چاق نشد.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">نتیجهگیری:</span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">پیشنهاد میشود میانسالان و سالمندان برای دستیابی هیپولپتینمی و هایپرآدیپونکتینمی، ترکیبی از مداخلات تمرین ورزشی و رژیم غذایی کم</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span cambria="" style="font-family:"></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span b="" lotus="" style="font-family:">کالری را در سبک زندگی خود قرار دهند.</span></span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:92%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Background:</span></b><span new="" roman="" style="font-family:" times=""> Leptin and adiponectin are adipokines produced by fat cells and play an important role in obesity. The purpose of this study was to compare the effect of low-calorie diet (LCD) and exercise (Exe) on leptin and adiponectin in middle-aged and elderly adults with overweight and obesity.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:92%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b> <span new="" roman="" style="font-family:" times="">A systematic search was conducted in PubMed, Web of Science, SID, Magiran, and Google scholar databases for English and Persian articles published until August 2023. The effect size and 95% confidence interval (CI) were calculated using the random effect model.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:92%"><span sans-serif="" style="font-family:Calibri,"><b><span new="" roman="" style="font-family:" times="">Results:</span></b> <span new="" roman="" style="font-family:" times="">The results of 25 studies with 2063 middle-aged and elderly people with overweight and obesity showed that the combination of exercise and diet compared to exercise alone causes a significant decrease in serum leptin [SMD=-0.4, P=0.001], and a significant increase in serum adiponectin [SMD=0.17, P=0.02] in middle-aged and elderly adults with overweight and obesity. Also, findings showed that the diet compared to exercise alone causes a decrease in serum leptin [SMD=-0.16, P=0.1], and a significant increase in serum adiponectin [SMD=0.05, P=0.7] in middle-aged and elderly adults with overweight and obesity. Also, diet compared to exercise alone does not cause a significant change in serum leptin [SMD=-0.11, P=0.2], and serum adiponectin [SMD=0.02, P=0.8] in middle-aged and elderly adults with overweight and obesity. </span><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b> <span new="" roman="" style="font-family:" times="">It is suggested that middle-aged and elderly people to achieve hypoleptinemia and hyperadiponectinemia, use a combination Include exercise training and low-calorie diet in your lifestyle.</span></span></span></span></span>
رژیم غذایی کمکالری, لپتین, آدیپونکتین, تمرین ورزشی, سالمندی
low-calorie diet, leptin, Adiponectin, Exercise, Aging
15
33
http://ijdld.tums.ac.ir/browse.php?a_code=A-10-1864-4&slc_lang=fa&sid=1
Fatemeh
Kazeminasab
فاطمه
کااظمی نسب
f_kazemi85@yahoo.com