Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
000
000
000
000
000
fa
jalali
1403
11
1
gregorian
2025
2
1
24
6
online
1
fulltext
fa
بررسی ارتباط سطوح سرمی GLP-1 با هورمونهای مرتبط به تیروئید و برخی از شاخصهای آنتروپومتریک پس از یک دوره تمرینهای کلیستنیکس در کودکان دیابتی
Investigating the Relationship between Serum GLP-1 Levels and Thyroid-Related Hormones and Some Anthropometric Indices after a Period of Calisthenics Exercises in Diabetic Children
عمومى
General
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt">مقدمه:</span></span></span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">بررسیهای بالینی نشان میدهد که دیابت بهعنوان یک اختلال متابولیکی میتواند کیفیت زندگی افراد مبتلا را تحت تأثیر قرار دهد و فعالیت بدنی ممکن است یک ابزار درمانی مؤثر در این افراد باشد</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">. در این پژوهش ارتباط سطوح سرمی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif">GLP-1</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">با هورمونهای تیروکسین، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif">TSH</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">، انسولین، گلوکز، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">HbA1c</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">، </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:#231f20">VO2max</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black"> و برخی از شاخصهای آنتروپومتریک بهدنبال هشت هفته </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">تمرینهای</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">کلیستنیکس بررسی شد.</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:"Calibri",sans-serif"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt">روشها</span></span></span></b><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.4pt">:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.4pt"> در این پژوهش نیمه تجربی 14 کودک غیرفعال مبتلابه دیابت نوع یک با میانگین سنی28/1</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"Cambria",serif"><span style="letter-spacing:-.4pt">±</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.4pt">42/12 سال بهطور غیر تصادفی انتخاب شدند و بهمدت هشت هفته (سه جلسه در هفته) تمرینهای کلیستنیکس را انجام دادند. اندازهگیریهای فیزیولوژیکی و نمونهگیری خون 48 ساعت قبل و پس از دورۀ تمرینی انجام شد. برای بررسی ارتباط از آزمون همبستگی پیرسن و برای اندازهگیری تغییرات درونگروهی از آزمون تی زوجی استفاده شد.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt">یافتهها:</span></span></span></span></b> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">نتایج نشان</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">دهندۀ وجود ارتباط مثبت و معنادار میان </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif">GLP-1</span></span></span><span style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""> <span lang="FA" style="color:black">و انسولین قبل</span></span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">(703/0 </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">r=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">، 005/0 </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">) و پس از مداخلۀ تمرینی (668/0 </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">r</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">، 009/0 </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">) بود. </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">همچنین <span style="color:black">ارتباط معکوس و معنادار</span> میان سطوح </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif">GLP-1</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif">WC</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""> قبل <span style="color:black">(633/0 </span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">r=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">، 019/0 </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">) و پس از تمرین (575/0 </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">r</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">، 043/0 </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">) و میان </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">GLP-1</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black"> و درصد چربی بدن پس از تمرین (676/0 </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">r</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">، 007/0 </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">P</span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:black">=</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:black">) دیده شد. در نتایج مربوط به تغییرات درونگروهی نیز افزایش معنادار </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif">GLP-1</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus"">، <span style="color:black">انسولین، </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:#231f20">VO2max</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:#231f20"> و کاهش معنادار </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"><span style="color:#231f20">WC</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="color:#231f20"> به دست آمد.</span></span></span></span><i><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:92%"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt"></span></span></span></span></i></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="tab-stops:right 0cm"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:"Calibri",sans-serif"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt">نتیجهگیری: </span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt">نتایج این مطالعه نشان میدهد که تمرین</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="letter-spacing:-.3pt"></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt">های</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"B Lotus""><span style="letter-spacing:-.3pt"> کلیستنیکس میتواند در کاهش آثار منفی ناشی از بیماری دیابت نوع یک و افزایش سلامتی کودکان دیابتی مؤثر باشد.</span></span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif">Background:</span></b><span style="font-family:"Times New Roman",serif"> Clinical studies have demonstrated that diabetes, as a metabolic disorder, can significantly impact the quality of life of individuals affected by the condition. Physical activity has been identified as a potentially effective therapeutic intervention for managing diabetes in these individuals</span><span style="font-family:"Times New Roman",serif">.</span> <span style="font-family:"Times New Roman",serif">This study examined the correlation between serum levels of GLP-1 and the hormones thyroxine, TSH, insulin, glucose, HbA1c, VO2max, as well as various anthropometric indicators after eight weeks of calisthenics exercises.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif">Methods:</span></b><span style="font-family:"Times New Roman",serif"> This semi-experimental study involved 14 sedentary children with type 1 diabetes, averaging 12.42±1.28 years, selected through non-random sampling.</span><span style="font-family:"Times New Roman",serif"> T</span><span style="font-family:"Times New Roman",serif">he participants </span><span style="font-family:"Times New Roman",serif"><span style="color:black">performed</span></span> <span style="font-family:"Times New Roman",serif">calisthenics exercises for eight weeks (three sessions per week). Physiological assessments and blood samples were collected 48 hours before and after the training period. The relationship was analyzed using Pearson's correlation test, and intra-group changes were assessed using paired t-tests. </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span style="tab-stops:45.8pt 91.6pt 137.4pt 183.2pt 229.0pt 274.8pt 320.6pt 366.4pt 412.2pt 458.0pt 503.8pt 549.6pt 595.4pt 641.2pt 687.0pt 732.8pt"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif">Results: </span></b><span style="font-family:"Times New Roman",serif">The findings demonstrated a positive and significant correlation between GLP-1 and insulin both before (r= 0.703, P= 0.005) and after the exercise intervention (r= 0.668, P= 0.009). Additionally, an inverse and significant correlation was observed between GLP-1 and waist circumference (WC) levels before (r= 0.633, P= 0.019) and after exercise (r= 0.575, P= 0.043), as well as between GLP-1 and body fat percentage after exercise (r= 0.676, P= 0.007).</span> <span style="font-family:"Times New Roman",serif">In terms of intra-group changes, the results indicated a significant increase in GLP-1, insulin, and VO2max, along with a significant decrease in WC.</span></span></span></span></span>
<pre style="text-align:justify">
<span style="font-size:10pt"><span style="line-height:92%"><span style="font-family:"Courier New""><b><span style="font-size:11.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif">Conclusion:</span></span></span></b><span style="font-size:11.0pt"><span style="line-height:92%"><span style="font-family:"Times New Roman",serif"> The findings of this study show that engaging in calisthenics exercises can be effective in reducing the negative effects of type 1 diabetes and increasing the health of diabetic children.</span></span></span></span></span></span></pre>
دیابت نوع یک, تمرینهای ورزشی, تیروکسین, پپتید شبیه به گلوکاگن 1
Diabetes Mellitus Type 1, Exercises, Thyroxine, Glucagon‐like Peptide‐1
356
365
http://ijdld.tums.ac.ir/browse.php?a_code=A-10-2120-1&slc_lang=fa&sid=1
Maryam
Nazari
مریم
نظری