fa تأثیر تمرینات تناوبی شدید بر سطوح پلاسمایی آیریزین و شاخص‌های گلایسمی در افراد چاق و دیابتی نوع دو: مرور نظام‌مند و فراتحلیل تخصصي Special مروري Review <span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="fa" style="font-size:11.0pt"><span style="font-weight:bold"><span b="" lotus="" style="font-family:">مقدمه:</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"> آیریزین، مایوکاین جدیدی است که از پروتئین غشایی </span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">FNDC5</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"> آزاد شده و تأثیرات مثبتی بر متابولیسم دارد. هدف از پژوهش حاضر، بررسی اثر تمرینات تناوبی شدید بر سطوح پلاسمایی آیریزین و شاخص‌های گلایسمی در افراد چاق و دیابتی نوع دو بود.</span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="fa" style="font-size:11.0pt"><span style="font-weight:bold"><span b="" lotus="" style="font-family:">روش‌ها: </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">جستجوی سیستماتیک مقالات انگلیسی و فارسی منتشر شده از پایگاه‌های اطلاعاتی</span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">PubMed </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">،</span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">Web of Science </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">، </span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">Scopus</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">، </span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">SID</span></span></span> <span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">و </span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">Magiran</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"> تا 30 آبان‌ماه 1403 (20 نوامبر2024) انجام شد. تفاوت میانگین و فاصله اطمینان 95 درصد (</span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">CI</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">) با استفاده از مدل اثر تصادفی محاسبه شد. ناهمگونی با استفاده از آزمون (</span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">I</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="vertical-align:super"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">2</span></span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">) و سوگیری انتشار با تحلیل بصری فونل پلات و آزمون </span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">Egger</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"> بررسی گردید.</span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="ar-SA" style="font-size:11.0pt"><span style="font-weight:bold"><span b="" lotus="" style="font-family:">یافته‌ها: </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">در مجموع 11 مطالعه و 264 آزمودنی چاق و دیابتی نوع دو وارد فراتحلیل حاضر شدند. نتایج نشان داد تمرین تناوبی شدید موجب افزایش معنادار آیریزین </span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">]</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">001</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">0</span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">P</span></span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">= </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">،</span></span> <span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">(616</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">0 الی280</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">2) </span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">ng/ml</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"> 448</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">1 </span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">WMD </span></span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">=</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">‌‌</span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">[</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">، کاهش معنادار گلوکز </span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">]</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">049</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">0</span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">P</span></span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">= </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">، (180</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">24- الی 074</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">0-) </span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">mg/dl</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"> 127</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">12-</span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed"> =</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">‌</span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">[</span></span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">WMD</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"> و مقاومت به انسولین </span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">]</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">001</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">0</span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">P</span></span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">= </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">،</span></span> <span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">(983</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">1- الی 567</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">0-)</span></span> <span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">275</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">1- </span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">=</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">‌</span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">[</span></span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">WMD </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">&nbsp;نسبت به گروه شاهد در افراد چاق و دیابتی نوع دو شد. در حالی که انسولین </span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">]</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">894</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">0</span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">P</span></span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">= </span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">،</span></span> <span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">(901</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">3- الی 402</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">3) </span></span>&nbsp;<span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">Iu/ml</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">249</span></span><span lang="en-US" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed">/</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:">0- </span></span><span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">=</span></span></span> <span lang="en-US" style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">[</span></span></span><span lang="en-US" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed">WMD</span></span></span><span lang="fa" style="font-size:11.0pt"><span b="" lotus="" style="font-family:"> کاهش معناداری نداشت.</span></span></span></span><br> <span style="font-size:11.0pt"><span style="direction:rtl"><span b="" lotus="" style="font-family:"><span style="unicode-bidi:embed"><span lang="ar-SA" style="font-weight:bold">نتیجه‌گیری: </span>روی هم‌رفته یافته‌های فراتحلیل حاضر نشان می‌دهد که تمرین تناوبی شدید نقش موثری در آیریزین، گلوکز، انسولین و مقاومت به انسولین به تمرینات تناوبی شدید ایفا می‌کند. تمرین تناوبی شدید، در افراد چاق و دیابتی موجب افزایش آیریزین، کاهش گلوکز، انسولین و مقاومت به انسولین می‌شود. اصلاح سبک زندگی و تمرین ورزشی، یک راهبرد درمانی ترجیحی در افراد چاق و دیابتی نوع دو است.</span></span></span></span><br> &nbsp; <span style="font-size:10.0pt"><span style="direction:rtl"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed"><span lang="en-US" style="font-weight:bold"><span style="unicode-bidi:embed">Background: </span></span><span lang="en-US" style="unicode-bidi:embed">Irisine is a new myokine that is released from the membrane protein fndc5 and has positive effects on metabolism. The aim of the present study was to investigate the effect of high-intensity interval training on plasma irisin levels and glycemic indices in obese and type 2 diabetic people.</span></span></span></span></span><br> <span style="font-size:10.0pt"><span style="direction:rtl"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed"><span lang="en-US" style="font-weight:bold"><span style="unicode-bidi:embed">Methods: </span></span><span lang="en-US" style="unicode-bidi:embed">A systematic search of published English and Persian articles was conducted from PubMed, Web of Science, Scopus, SID, and Magiran databases up to 20 November 2024. The mean difference and 95% confidence interval (CI) were calculated using a random-effects model. Heterogeneity was assessed using the (I</span><span lang="en-US" style="vertical-align:super"><span style="unicode-bidi:embed">2</span></span><span lang="en-US" style="unicode-bidi:embed">) test and publication bias was assessed using visual analysis of funnel plots and Egger&#39;s test.</span></span></span></span></span><br> <span style="font-size:10.0pt"><span style="direction:rtl"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed"><span lang="en-US" style="font-weight:bold"><span style="unicode-bidi:embed">Results: </span></span><span lang="en-US" style="unicode-bidi:embed">A total of 11 studies and 264 obese and type 2 diabetic subjects were included in the present meta-analysis. The results showed that high-intensity interval training significantly increased irisin [WMD = 1.448 ng/ml (2.280 to 0.616), P= 0.001],</span> <span lang="en-US" style="unicode-bidi:embed">significantly decreased glucose [WMD = -12.127 mg/dl (-24.180 to -0.074), P= 0.049]</span> <span lang="en-US" style="unicode-bidi:embed">and insulin resistance [WMD= -1.275 (-0.567 to -1.983), P= 0.001]</span> <span lang="en-US" style="unicode-bidi:embed">compared to the control group in obese and type 2 diabetic subjects. While insulin [WMD= -0.249Iu/ml (3.402 to -3.901), P= 0.894]</span> <span lang="en-US" style="unicode-bidi:embed">was not significantly reduced.</span></span></span></span></span><br> <span style="font-size:10.0pt"><span style="direction:rtl"><span new="" roman="" style="font-family:" times=""><span style="unicode-bidi:embed"><span lang="en-US" style="font-weight:bold"><span style="unicode-bidi:embed">Conclusion: </span></span><span lang="en-US" style="unicode-bidi:embed">Overall, the findings of the present meta-analysis indicate that high-intensity interval training plays an effective role in irisin, glucose, insulin, and insulin resistance to high-intensity interval training. High-intensity interval training increases irisin, decreases glucose, insulin, and insulin resistance in obese and diabetic individuals. Lifestyle modification and exercise training are preferred treatment strategy in obese and type 2 diabetic people.</span></span></span></span></span> تمرین تناوبی شدید, آیریزین, شاخص‌های گلایسمی, چاق, دیابتی نوع دو 85 100 http://ijdld.tums.ac.ir/browse.php?a_code=A-10-2162-1&slc_lang=fa&sid=1 Abbas Saremi عباس صارمی 0000-0002-0113-1497 No Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran گروه فیزیولوژی ورزش، دانشکدۀ علوم ورزشی،دانشگاه اراک، اراک، ایران Omid Zafarmand امید ظفرمند OMIDZAFARMAND2202@GMAIL.COM 0000-0002-8626-2364 Yes Department of Physical Education and Sports Sciences, School of Humanities, University of Yasouj, Yasouj, Iran گروه تربیت بدنی و علوم ورزشی، دانشکدۀ علوم انسانی، دانشگاه یاسوج، یاسوج، ایران