Iranian Journal of

Background: Diabetes accompanies with hormonal, biochemical changes, and metabolic damages are of body. So in this research, therapeutic effect of the blue mesocarp extract on streptozotocin diabetes has been discussed.

Methods: 30 adult Westar rats were divided into five groups six below. Witness group: that at the same time by injecting (STZ) to diabetic rats citrate buffer has been injected into them as the attribute. First experimental group: became diabetes by injecting 55mg/kg (STZ). Second experimental group and Third experimental group and Fourth experimental group: including six diabetic rats that were treated by injecting daily 100, 150& 200mg blue mesocarp extract of walnut end of week 13direct bloodletting from the heart has been achieved due to study of One way anova and a further test of TUKEY were consumed then samples were delivered to the lab for insulin hormone and blood sugar measuring

Results: In the treated group there was a meaningful decrease in blood sugar in all doses of blue mesocarp extract of walnut than diabetic group and also a meaningful increase in serum's ansoline level and body weight in treated group than diabetic group. This study for the first time showed that using blue mesocarp extract of walnut in long period, meaningfully decreases blood sugar in diabetic rats and it causes the meaningful increase of serum's ansoline in treated group.

Conclusion: diabetes redounds to decrease of ansoline hormone and increase of blood sugar by making free radicals and oxidative stresses. Blue mesocarp extract with ability of prevent and treating of oxidative stresses has an important role in improving the consequences of diabetes and also the increase of ansoline hormone.