Volume 17, Issue 4 (5-2018)                   ijdld 2018, 17(4): 198-205 | Back to browse issues page

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Ghafari M, Faramarzi M, Banitalebi E. Compar Two Different Endurance Training Intensities On Perilipin 3 Protein Expression In Skeletal Muscle, Serum Glucose Levels And Insulin In Streptozotocin-Induced Diabetic Rats. ijdld. 2018; 17 (4) :198-205
URL: http://ijdld.tums.ac.ir/article-1-5768-en.html
1- Department of Exercise physiology, University of Shahrekord, Shahrekord ,Iran , ghafari.mehdi@gmail.com
2- Department of Exercise physiology, University of Shahrekord, Shahrekord ,Iran
Abstract:   (1211 Views)
Background: Lipid metabolism disorder in muscle plays an important role in creating insulin resistance in skeletal muscle. Perilipin 3 (PLIN3) is one of PLIN proteins in regulation of muscle lipolysis. The purpose of this study was compared two different endurance training intensities on perilipin 3 protein expression in skeletal muscle, serum insulin levels and glucose in streptozotocin-induced diabetic rats.
Method: 24 male Wistar rats were randomly divided into three groups. Low and high and high-intensity and control group. Endurance training was applied three times a week for eight weeks. The low-intensity exercise group was trained to the treadmill by running at a speed of 60 percent of vo2max and high-intensity training 85%Vo2max. The expression of the plin2 protein was analyzed by Western blot technique. To determine the significance of differences between the groups, the results were analyzed using one-way ANOVA and Tukey post-hoc test (α= 0.05).
Results: Direct comparison between the groups by ANOVA showed significant differences in perilipin 3 (p=0.0006). Tukey's post hoc test showed that there was a statistical difference between the mean values of the diabetic control group and high-intensity endurance group (P = 0.01). Perilipin 3 not significantly increased in low-intensity exercise compared to the control group (P=0. 67). Also, the comparison between groups showed, there was significant difference between the three groups. The serum levels of glucose and insulin (respectively p=0.001 and p=.001).
Conclusion: The results of the present study showed that the Effects of with high-intensity endurance training increase the expression perilipin 3 in diabetes rats.
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Received: 2018/09/23 | Accepted: 2018/09/23 | Published: 2018/09/23

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