Volume 5, Issue 1 (18 2005)                   ijdld 2005, 5(1): 49-58 | Back to browse issues page

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Tabatabaei Malazy O, Heshmat R, Hejazy Mogaddam SA S A, Taheri E, Soheilykhah S, Darvishzadeh F et al . COMPARISON OF TWO TYPES OF METFORMIN (ARIA CO. AND MERCK CO) IN TYPE 2 DIABETIC PATIENTS:DOUBLE BLIND RANDOMIZED CLINICAL TRIAL. ijdld. 2005; 5 (1) :49-58
URL: http://ijdld.tums.ac.ir/article-1-383-en.html
Abstract:   (19734 Views)
Background: Metformin is usually using for glycemic control in type 2 diabetes mellitus. The drug is the first line for obese patients without renal or liver failure. Different pharmaceutical types of Metformin are available. As a clinical trial, we compared effects of Aria Metformin (product of Aria pharmaceutical company, Iran) with Merck Metformin or Glucophage (product of Merck pharmaceutical company, France), in diabetic patients.
Methods: This double blind randomized clinical trial study performed with 60 non- pregnant diabetic patients, in order to comparison of therapeutic effects of combination therapy (Glibenclamide + Metformin "Aria or Merck") in a 12 weeks period. We evaluated FBS, BS 2hpp, HbA1c, lipid profile, liver function tests, weight, BMI and common or uncommon side effects.
Results: Not only each of two pharmaceutical types of Metformin had the same therapeutic effects for controlling of glycemia, lipid profile and weight, but also there were not difference between them in side effects. Distention was the most common side effects of two types products (33%). There is not significant difference between them in common side effects. 70% of patients were satisfied with each two kinds of Metformin.
Conclusion: It seems, in view of beneficial therapeutic effects of Aria Metformin, low rate of side effects, and finally low cost, Aria Metformin is a good choice.
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Type of Study: Research | Subject: General
Received: 2005/09/3 | Accepted: 2005/11/21 | Published: 2013/10/1

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