Volume 14, Issue 1 (1-2015)
ijdld 2015, 14(1): 9-14 |
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Sazegar G, Ebrahimi V, Saeedi Boroujeni M J, Mohammadi S, Salimnezhad R. MORPHOMETRIC STUDY OF TESTIS TISSUE AND SPERMATOGENESIS FOLLOWING CARNITINE ADMINISTRATION IN DIABETIC RAT INDUCED WITH STEREPTOZOTOCIN. ijdld 2015; 14 (1) :9-14
URL: http://ijdld.tums.ac.ir/article-1-5316-en.html
URL: http://ijdld.tums.ac.ir/article-1-5316-en.html
Ghasem Sazegar1 
, Vahid Ebrahimi1 , Mohammad Javad Saeedi Boroujeni1 , Shabnam Mohammadi * 2, Ramin Salimnezhad1
, Vahid Ebrahimi1 , Mohammad Javad Saeedi Boroujeni1 , Shabnam Mohammadi * 2, Ramin Salimnezhad1
1- 1. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- 1. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran/ 2. Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,mohammadish881@mums.ac.ir
2- 1. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran/ 2. Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (7680 Views)
Background: Given diabetes mellitus has an adverse effect on spermatogenesis and male fertility, the aim of the present study was to investigate the effect of L-carnitine administration on spermatogenesis and testicular structure in diabetic rats induced with Stereptozotocin.
Methods: In this experimental study, fifteen rats were randomly divided into 3 groups: control group was received citrate buffer. Case group was diabetic rats that received 40 mg/kg carnitine for 16 days. Third group was diabetic rats that did not receive carnitine. After sixteen days, morphometric study was performed. Besides, index of testicular weight was obtained. Then, data were analyzed using SPSS software and ANOVA.
Results: In testicular sections of diabetic rats were observed a disruption and deformity in first layer of somniferous tubules. Statistical analysis showed a significant difference in carnitine group when compared to the control group (P<0.05). There was a significant difference between weight of diabetic rat compared to the control group (P<0.001). Besides, there was the most ratio of testis index in control group.
Conclusion: Our finding showed that short-term L-carnitine administration was affective on the diameter and thickness of seminiferous tubules. Hence, L-carnitine treatment may cause an improvement in spermatogenesis of diabetic men.
Type of Study: Research |
Subject:
General
Received: 2015/02/9 | Accepted: 2015/02/9 | Published: 2015/02/9
Received: 2015/02/9 | Accepted: 2015/02/9 | Published: 2015/02/9
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