Volume 17, Issue 3 (3-2018)                   ijdld 2018, 17(3): 117-124 | Back to browse issues page

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Moradi M, Ravasi A, Khalafi M, Talebi V. The Effect Of A High Intensity Interval Exercise (Hiie) On Hypothalamic Nesfatin-1 Gene Expression Of Diabetic Male Rats. ijdld. 2018; 17 (3) :117-124
URL: http://ijdld.tums.ac.ir/article-1-5686-en.html
1- Department of Exercise Physiology, Faculty of Physical Education, Tehran University, Tehran, Iran , m.moradi13@ut.ac.ir
2- Department of Exercise Physiology, Faculty of Physical Education, Tehran University, Tehran, Iran
3- Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Mazandaran, Iran
4- Department of Exercise Physiology, Faculty of Physical Education, University of Gilan, Rasht, Iran
Abstract:   (2650 Views)
Background: Nesfetin-1 is known as the peptide which interfere in appetite and glucose hemostasis. The aim of the present study is to investigate the effects of two kinds of acute exercise to nesfatin-1 gene expression of diabetic rats.
Methods: In this study, has utilized the diabetic vistar staggy rats with STZ (12 week-age, 220-240 gr-weight). Animals were divided into four group: high DIABETIC MALE RATSintensity interval exercise (HIIE-0), control (C-0), (witch immediately has murdered after the exercise) and high intensity interval exercise (HIIE-2), and control (C-2), (which has murdered 2 hours after the exercise). HIIE group activated on the treadmill with 25 and 14 meter/minute in the 12 interval-one-minute period.
 Results: After removing hypothalamus and extraction of RNA, has down RT.PCR. The Independent T test analyzed and level of significance has been considering at 0/01 The exercise activity caused the significant increase of gene expression in the HIIE-0 group (P=0/001). But there was not significant increase in the HIIE-2 group (P=0/234).
 Conclusion: The results of this study displayed that one session of high intensity interval activity caused an increase immediately after the exercise in the hypothalamic nesfatin-1 gene expression of vistar staggy rats.
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Type of Study: Research | Subject: Special
Received: 2018/02/6 | Accepted: 2018/04/19 | Published: 2018/10/13

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