Volume 19, Issue 4 (4-2020)                   ijdld 2020, 19(4): 217-224 | Back to browse issues page

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Fakhraei Nasab A, Aghaei Meybodi H R, Afshari M, Sarhangi N, Hasanzad M. INVESTIGATING THE ROLE OF MTNR1B RS4753426 GENETIC VARIANT IN THE TYPE 2 DIABETES MELLITUS RISK. ijdld. 2020; 19 (4) :217-224
URL: http://ijdld.tums.ac.ir/article-1-5947-en.html
1- Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran
4- Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , mandanahasanzad@yahoo.com
Abstract:   (222 Views)
Background: Type 2 diabetes Mellitus (T2DM) is a multifactorial, polygenic disease caused by impaired insulin secretion, insulin resistance and beta-cell dysfunction. Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. Melatonin and the genetic variants of MTNR1B gene are reported to be associated with T2DM susceptibility. We investigated the association between rs4753426 variant in the MTNR1B gene and the risk of T2DM in group of Iranian patients.
Methods: In this case-control study108 T2DM and 100 normal individuals were recruited to genotyping by PCR- RFLP.
Results: It was observed a significant difference in CC, CT, and TT genotypes distribution between T2DM and control groups (P<0.001). Frequency of C allele among cases was significantly lower than controls (8.3% vs. 42.5% respectively, P<0.001) and C allele carriers had a 88% lower risk of developing T2DM than T carriers.
Conclusion: Our results showed that the rs4753426 variant of MTNR1B gene could reduce the risk of T2DM developing.
Full-Text [PDF 950 kb]   (97 Downloads)    
Type of Study: Research | Subject: Special
Received: 2020/05/23 | Accepted: 2020/04/29 | Published: 2020/04/29

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