Volume 21, Issue 3 (9-2021)
ijdld 2021, 21(3): 129-138 |
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Nabilpour M, Sadeghi A. Effect of Eight-Week Aerobic Moderate-Intensity Continuous Training on Il-1β and Il-13 Levels of Soleus Muscle Tissue in Male Diabetic Rats. ijdld 2021; 21 (3) :129-138
URL: http://ijdld.tums.ac.ir/article-1-6006-en.html
URL: http://ijdld.tums.ac.ir/article-1-6006-en.html
1- Department of Exercise Physiology, University of Mohagheghe Ardebili, Ardebil, Iran
2- Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran , sadeghi@soc.ikiu.ac.ir
2- Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran , sadeghi@soc.ikiu.ac.ir
Abstract: (1636 Views)
Background: One consequence of diabetes mellitus is increased inflammation, which is exacerbated by training. The objective of this study was to evaluate the effect of eight weeks of aerobic moderate-intensity continuous training on Interleukin-1 beta, Interleukin-13 responses in male Wistar diabetic rats.
Methods: 36 diabetic rats were randomly assigned into 3 equal groups (control (C), diabetic (D), and diabetes + training (D + T)), and subjected to eight weeks of aerobic moderate- intensity continuous training intensity at the first: the10 min on 10m/min and at the final: 55min on 26m/min speed. Interleukin-1 and interleukin-13 were measured in soleus muscle tissue to examine the pro-inflammatory and anti-inflammatory indicators. ANOVA and Scheffe post hoc tests were used for data analysis.
Results: Induction of diabetes caused a significant increase in IL-1β and IL-13 (P<0.001) and continuous exercise intervention also significantly reduced IL-1β levels in diabetic rats (P = 0.02). However, there was no significant change in IL-13 in D + T group compared to D group (P = 0.985).
Conclusion: According to the results of this study, the effect of aerobic exercise is probably a positive effect on reducing the pro-inflammatory index of IL-1β and no effect on the anti-inflammatory index of IL-13 in diabetic rats. However, definitive confirmation of these results requires further research in this area.
Methods: 36 diabetic rats were randomly assigned into 3 equal groups (control (C), diabetic (D), and diabetes + training (D + T)), and subjected to eight weeks of aerobic moderate- intensity continuous training intensity at the first: the10 min on 10m/min and at the final: 55min on 26m/min speed. Interleukin-1 and interleukin-13 were measured in soleus muscle tissue to examine the pro-inflammatory and anti-inflammatory indicators. ANOVA and Scheffe post hoc tests were used for data analysis.
Results: Induction of diabetes caused a significant increase in IL-1β and IL-13 (P<0.001) and continuous exercise intervention also significantly reduced IL-1β levels in diabetic rats (P = 0.02). However, there was no significant change in IL-13 in D + T group compared to D group (P = 0.985).
Conclusion: According to the results of this study, the effect of aerobic exercise is probably a positive effect on reducing the pro-inflammatory index of IL-1β and no effect on the anti-inflammatory index of IL-13 in diabetic rats. However, definitive confirmation of these results requires further research in this area.
Type of Study: Research |
Subject:
Special
Received: 2020/11/29 | Accepted: 2021/05/1 | Published: 2021/09/1
Received: 2020/11/29 | Accepted: 2021/05/1 | Published: 2021/09/1
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