Volume 22, Issue 3 (9-2022)
ijdld 2022, 22(3): 165-174 |
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Arabloei sani M, Yaghmaei P, Hajebrahimi Z, Hayati Roodbari N. The anti-diabetic potential of P-Cymene monoterpene on serum factor levels and SOD assay in STZ-diabetic male rats. ijdld 2022; 22 (3) :165-174
URL: http://ijdld.tums.ac.ir/article-1-6140-en.html
URL: http://ijdld.tums.ac.ir/article-1-6140-en.html
1- Department of Physiology Animal Biology, college of convergent sciences and Technologies, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Physiology Animal Biology, college of convergent sciences and Technologies, Sciences and Research Branch, Islamic Azad University, Tehran, Iran ,yaghmaei_p@srbiau.ac.ir
3- Aerospace Research Institute, Ministry of Science Research and Technology, Tehran, Iran
4- Department of Cellular and Developmental Animal Biology, college of convergent sciences and Technologies, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Physiology Animal Biology, college of convergent sciences and Technologies, Sciences and Research Branch, Islamic Azad University, Tehran, Iran ,
3- Aerospace Research Institute, Ministry of Science Research and Technology, Tehran, Iran
4- Department of Cellular and Developmental Animal Biology, college of convergent sciences and Technologies, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
Abstract: (925 Views)
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong association between hyperglycemia, oxidative stress and the development of diabetes. Therefore, screening and early diagnosis of this disease in people at high risk can be effective in preventing these complications. The main route of insulin signaling is to control lipid and glucose metabolism, and its imbalance leads to type 2 diabetes. P-Cymene is an aromatic monoterpene with a wide range of therapeutic properties including antioxidant activity. The aim of this study was to evaluate the effect of p-Cymene at a dose of 50 mg / kg in preventing the symptoms of diabetes and serum factors.
Materials and Methods: 30 male Wistar rats weighing approximately 250 g were randomly selected and divided into five groups: control, diabetic control (sham), metformin-treated diabetic (met), and non-diabetic treated. P-Cymene and diabetics treated with P-Cymene were divided. One week after streptozotocin injection, treatment with P-Cymene at a dose of 50 mg / kg was performed by sunflower oil solvent for 28 days by gavage. At the end of the experiment, blood samples were taken from the hearts of rats and the parameters of glucose, insulin, and superoxide dismutase (SOD) were measured.
Results: The results showed that diabetes increased water and food intake as well as glucose levels and decreased insulin (P <0.001) and superoxide dismutase activity in rats and administration of P-Cymene extract improved the symptoms of diabetes and oxidative stress in Became diabetic rat.
Materials and Methods: 30 male Wistar rats weighing approximately 250 g were randomly selected and divided into five groups: control, diabetic control (sham), metformin-treated diabetic (met), and non-diabetic treated. P-Cymene and diabetics treated with P-Cymene were divided. One week after streptozotocin injection, treatment with P-Cymene at a dose of 50 mg / kg was performed by sunflower oil solvent for 28 days by gavage. At the end of the experiment, blood samples were taken from the hearts of rats and the parameters of glucose, insulin, and superoxide dismutase (SOD) were measured.
Results: The results showed that diabetes increased water and food intake as well as glucose levels and decreased insulin (P <0.001) and superoxide dismutase activity in rats and administration of P-Cymene extract improved the symptoms of diabetes and oxidative stress in Became diabetic rat.
Type of Study: Research |
Subject:
Special
Received: 2022/04/12 | Accepted: 2022/07/26 | Published: 2022/09/1
Received: 2022/04/12 | Accepted: 2022/07/26 | Published: 2022/09/1
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