Volume 23, Issue 1 (5-2023)
ijdld 2023, 23(1): 24-33 |
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Babaee S, Peere M, Azarbayjani M A, Delfan M. The Effect of Four Weeks of High Intensity Interval Training with Curcumin Supplement on the Expression of IRS-1 and IRE-1α Genes in the Left Ventricle of Type 2 Diabetic Rats. ijdld 2023; 23 (1) :24-33
URL: http://ijdld.tums.ac.ir/article-1-6210-en.html
URL: http://ijdld.tums.ac.ir/article-1-6210-en.html
1- Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran ,m.peeri@iauctb.ac.ir
3- Department of exercise physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran ,
3- Department of exercise physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran
Abstract: (664 Views)
Impaired insulin function with exogenous changes is a major cause of heart failure. The purpose of this study was to investigate the effect of four weeks of high intensity interval training with curcumin supplement on the expression of IRS-1 and IRE-1α gene in the Left ventricle of type 2 diabetic rats.
Methods: In the present experimental study, 30 male mice with diabetes were divided into five groups of 6; high intensity interval training (HIIT), High intensity interval Training+Curcumin(S+HIIT), Diabetic control+curcumin(S+DC), Diabetic Control (DC), Normal control (NC). The High intensity interval training protocol was performed five days a week for four weeks. Curcumin gavage at a dose of 100 mg/kg was performed daily. The expression of IRS-1 and IRE-1α were measured by the qReal-TimePCR method, and data were analyzed by one-way ANOVA at the alpha level of 0.05.
Results: IRS-1 gene expression in the S+HIIT group compared to the DC (P=0.003) and S+DC (P=0.001) groups and in the HIIT group compared to the DC (P=0.002), and S groups +DC had a significant decrease (P=0.019). IRE-1α gene was significantly decreased in S+HIIT group compared to DC (P=0.003), S+DC (P=0.001) and HIIT (P=0.008) groups.
Conclusion: It seems that HIIT with curcumin supplement can reduce the process of myocardial apoptosis in diabetic patients by improving metabolic conditions and genetic factors.
Methods: In the present experimental study, 30 male mice with diabetes were divided into five groups of 6; high intensity interval training (HIIT), High intensity interval Training+Curcumin(S+HIIT), Diabetic control+curcumin(S+DC), Diabetic Control (DC), Normal control (NC). The High intensity interval training protocol was performed five days a week for four weeks. Curcumin gavage at a dose of 100 mg/kg was performed daily. The expression of IRS-1 and IRE-1α were measured by the qReal-TimePCR method, and data were analyzed by one-way ANOVA at the alpha level of 0.05.
Results: IRS-1 gene expression in the S+HIIT group compared to the DC (P=0.003) and S+DC (P=0.001) groups and in the HIIT group compared to the DC (P=0.002), and S groups +DC had a significant decrease (P=0.019). IRE-1α gene was significantly decreased in S+HIIT group compared to DC (P=0.003), S+DC (P=0.001) and HIIT (P=0.008) groups.
Conclusion: It seems that HIIT with curcumin supplement can reduce the process of myocardial apoptosis in diabetic patients by improving metabolic conditions and genetic factors.
Keywords: Myocrdial Apoptosis, Cardiomyopathy, Curcumin Supplement, High Intensity Interval Training
Type of Study: Research |
Subject:
Special
Received: 2023/01/18 | Accepted: 2023/03/19 | Published: 2023/05/31
Received: 2023/01/18 | Accepted: 2023/03/19 | Published: 2023/05/31
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