Volume 23, Issue 5 (12-2023)
ijdld 2023, 23(5): 297-309 |
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ketabdar A, Attarzadeh hosseini S R, Fathei M, Mosaferi M. The Effect of Eight Weeks of Endurance Training and Growth Hormone Injections on Cardiac Mitochondrial PGC1α Content and Some Oxidative Stress Indices in Mice with Hepatic Damage. ijdld 2023; 23 (5) :297-309
URL: http://ijdld.tums.ac.ir/article-1-6240-en.html
URL: http://ijdld.tums.ac.ir/article-1-6240-en.html
1- Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2- Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran , srezaattarzadehhosseini@gmail.com
2- Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran , srezaattarzadehhosseini@gmail.com
Abstract: (502 Views)
Background: Fatty liver disease and its relationship with cardiovascular diseases is one of the concerns of today's society, therefore the present study was conducted to investigate the effect of eight weeks of endurance training and growth hormone injections on Cardiac mitochondrial PGC1α content and some oxidative stress indices in mice with hepatic damage.
Methods: In this experimental study, 21 male mice were, randomly, divided into three groups (n=7): control (C), Exercise (E), Exercise + Growth Hormone (EGH) group. The Medium intensity endurance training program was performed for eight weeks and 5 sessions with an intensity of 50% VO2max of per week. The somatropin injection protocols were 1 mg/ kilogram/body weight, respectively. Statistical analysis of the data was performed using the software SPSS, using One-Way ANOVA and post hoc Tukey tests.
Results: PGC1a levels increased in both groups compared to the control group. SOD and MDA levels increased and decreased in both groups compared to the control group, respectively. The reduction of HOMA levels was significant only in E group compared to the control group. Also, the difference between E and E-GH group was significant. ALT/AST ratio decreased in both groups compared to the control group. The reduction of LDL/HDL ratio was significant only in group E compared to the control group.
Conclusion: Endurance training has produced a more effective response in improving NAFLD markers than GH peptides. Growth hormone injection can have negative consequences on some indicators of this abnormality.
Methods: In this experimental study, 21 male mice were, randomly, divided into three groups (n=7): control (C), Exercise (E), Exercise + Growth Hormone (EGH) group. The Medium intensity endurance training program was performed for eight weeks and 5 sessions with an intensity of 50% VO2max of per week. The somatropin injection protocols were 1 mg/ kilogram/body weight, respectively. Statistical analysis of the data was performed using the software SPSS, using One-Way ANOVA and post hoc Tukey tests.
Results: PGC1a levels increased in both groups compared to the control group. SOD and MDA levels increased and decreased in both groups compared to the control group, respectively. The reduction of HOMA levels was significant only in E group compared to the control group. Also, the difference between E and E-GH group was significant. ALT/AST ratio decreased in both groups compared to the control group. The reduction of LDL/HDL ratio was significant only in group E compared to the control group.
Conclusion: Endurance training has produced a more effective response in improving NAFLD markers than GH peptides. Growth hormone injection can have negative consequences on some indicators of this abnormality.
Type of Study: Research |
Subject:
Special
Received: 2023/05/27 | Accepted: 2023/08/20 | Published: 2023/12/31
Received: 2023/05/27 | Accepted: 2023/08/20 | Published: 2023/12/31
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