Volume 24, Issue 1 (3-2024)
ijdld 2024, 24(1): 47-56 |
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Azizi M, Mokhari Domakani F, Baledi R. The Effect of Eight Weeks' Aerobic Exercise Protocol on Murf1 Gene Expression in Cardio-Myocyte of Diabetic Wistar Rats. ijdld 2024; 24 (1) :47-56
URL: http://ijdld.tums.ac.ir/article-1-6274-en.html
URL: http://ijdld.tums.ac.ir/article-1-6274-en.html
1- Department of Physical Educatin, Abadan Branch, Islamic Azad University, Abadan, Iran , scienceinsport@yahoo.com
2- Department of Physical Educatin, Abadan Branch, Islamic Azad University, Abadan, Iran
2- Department of Physical Educatin, Abadan Branch, Islamic Azad University, Abadan, Iran
Abstract: (276 Views)
Background: Diabetic cardiomyopathy is one of the main risk factors related to diabetes, which can be caused by atrophy of the cardiomocytes. It is supposed that the MuRF1 gene intermediate as an agent for heart atrophy. Hence, the purpose of current study was to investigate the effect of eight weeks' aerobic exercise protocol on murf1 gene expression in cardio-myocyte of diabetic Wistar rats.
Methods: In this study, 30 male Wistar rats with an age of eight weeks and an average weight of 288 grams were randomly divided into three groups of 10 including healthy control, diabetic control and aerobic exercise group after two weeks of adaptation to the environment. The exercise groups went under aerobic training programs using treadmill (5 days/wks., for 8 wks.) 60%-75% Vo2max. MuRF1 mRNA level was measured in cardio myocyte using Real-Time PCR. The results were compared by statistical methods.
Results: The changes in the expression of Murf1 genes expression in cardio-myocyte of diabetes group were significantly higher than the other groups (P< .05). The expression of Murf1 gene in continuous training group reduced significantly after eight weeks' aerobic exercise training (P󠇟< .05).
Conclusion: This study demonstrated that eight weeks' aerobic exercise training can lead to reduction of Murf1 genes expression level and might be a good prescription for diabetic persons. However, further studies are needed to confirm this theory.
Methods: In this study, 30 male Wistar rats with an age of eight weeks and an average weight of 288 grams were randomly divided into three groups of 10 including healthy control, diabetic control and aerobic exercise group after two weeks of adaptation to the environment. The exercise groups went under aerobic training programs using treadmill (5 days/wks., for 8 wks.) 60%-75% Vo2max. MuRF1 mRNA level was measured in cardio myocyte using Real-Time PCR. The results were compared by statistical methods.
Results: The changes in the expression of Murf1 genes expression in cardio-myocyte of diabetes group were significantly higher than the other groups (P< .05). The expression of Murf1 gene in continuous training group reduced significantly after eight weeks' aerobic exercise training (P󠇟< .05).
Conclusion: This study demonstrated that eight weeks' aerobic exercise training can lead to reduction of Murf1 genes expression level and might be a good prescription for diabetic persons. However, further studies are needed to confirm this theory.
Type of Study: Research |
Subject:
Special
Received: 2023/08/8 | Accepted: 2023/10/31 | Published: 2024/03/29
Received: 2023/08/8 | Accepted: 2023/10/31 | Published: 2024/03/29
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