Volume 24, Issue 5 (12-2024)
ijdld 2024, 24(5): 281-290 |
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Yavari G, molzemi S, Hojati V, Kordi Z. Study of the Effect of the Hydraulic Extract of the Mascara (Vicia Sativa) on Skin Wounds in Diabetic Desert Mice with Streptozocin. ijdld 2024; 24 (5) :281-290
URL: http://ijdld.tums.ac.ir/article-1-6331-en.html
URL: http://ijdld.tums.ac.ir/article-1-6331-en.html
1- Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
2- Department of tissue engineering and applied cell sciences, school of advanced technologies in medicine, shahid beheshti univercity of medical sciences, Tehran, Iran ,saharmolzemi@yahoo.com
3- Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
4- Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran
2- Department of tissue engineering and applied cell sciences, school of advanced technologies in medicine, shahid beheshti univercity of medical sciences, Tehran, Iran ,
3- Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
4- Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran
Abstract: (490 Views)
Background: Dysfunction of pancreatic beta cells causes a decrease in insulin and an increase in serum glucose, resulting in diabetes. Diabetes has caused dysfunction by damaging various organs, including tissues that are at risk of diabetes. So we've looked at the effect of Vicia sativa on skin wounds caused by high blood sugar.
Methods: In this study, 48 male mouse heads of the wistar breed with a weight range of 220 to 250 grams were divided into 4 control groups, Shem, experimental one (diabetic group+ oserin), experimental two(diabetic+ V. sativa). At the same time as the mice became diabetic with a dose of 50 mg/kg streptosotocin, the rest of the groups received the citrate buffer intra-peritoneal. After the rats were unconscious with the anesthetic and their back hair was shaved in the 3 cm long test groups on the left side of the spine, and the treated groups were treated with 14 days of MG/kg200 dose of mascara extract on the wounds. The wound healing process was examined macroscopically and microscopically on days 7 and 14.
Results: The wound of diabetic groups treated with streptozocin showed a later repair compared to the control group, and the wound healing was faster in experimental groups treated with alcoholic extract of the mascara than in the control group.
Conclusion: The results indicated that the alcoholic extract of the mascara accelerated the healing of skin wounds of healthy and diabetic samples.
Methods: In this study, 48 male mouse heads of the wistar breed with a weight range of 220 to 250 grams were divided into 4 control groups, Shem, experimental one (diabetic group+ oserin), experimental two(diabetic+ V. sativa). At the same time as the mice became diabetic with a dose of 50 mg/kg streptosotocin, the rest of the groups received the citrate buffer intra-peritoneal. After the rats were unconscious with the anesthetic and their back hair was shaved in the 3 cm long test groups on the left side of the spine, and the treated groups were treated with 14 days of MG/kg200 dose of mascara extract on the wounds. The wound healing process was examined macroscopically and microscopically on days 7 and 14.
Results: The wound of diabetic groups treated with streptozocin showed a later repair compared to the control group, and the wound healing was faster in experimental groups treated with alcoholic extract of the mascara than in the control group.
Conclusion: The results indicated that the alcoholic extract of the mascara accelerated the healing of skin wounds of healthy and diabetic samples.
Type of Study: Research |
Subject:
Special
Received: 2024/02/7 | Accepted: 2024/04/30 | Published: 2024/12/30
Received: 2024/02/7 | Accepted: 2024/04/30 | Published: 2024/12/30
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