Volume 24, Issue 6 (2-2025)
ijdld 2025, 24(6): 405-416 |
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Saebi F, Abednatanzi H, Azarbayejani M A, Gholami M. Changes in GLUT4 Gene Expression in Soleus Muscle Tissue and Insulin Resistance Index After HIIT and Consumption of Chromosome Royal Gel in Type 2 Diabetic Obese Rats. ijdld 2025; 24 (6) :405-416
URL: http://ijdld.tums.ac.ir/article-1-6355-en.html
URL: http://ijdld.tums.ac.ir/article-1-6355-en.html
1- Department of physical education and sport science, Science and research branch, Islamic Azad University, Tehran, Iran
2- Department of physical education and sport science, Science and research branch, Islamic Azad University, Tehran, Iran ,abednazari@gmail.com
3- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Central Tehran Branch, Tehran, Iran
2- Department of physical education and sport science, Science and research branch, Islamic Azad University, Tehran, Iran ,
3- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Central Tehran Branch, Tehran, Iran
Abstract: (344 Views)
Background: Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between insulin demand and reserves. Glucose transport to the muscle fiber is carried out by glucose transporter proteins (GLUTs). GLUT4 is the most important glucose transporter isoform in skeletal muscles. Insulin and exercise stimulate the fast and intense transfer of GLUT4 to the plasma membrane and cause the absorption of glucose in muscle and fat tissue. The aim of the present study was to study the changes in GLUT4 gene expression in soleus muscle tissue and insulin resistance index after HIIT and royal jelly in type 2 diabetic obese rats.
Methods: The statistical subject consisted of wistar rats became diabetic after a 20 weeks high-fat diet by intraperitoneal injection of 25 mg/kg STZ. Rats with fasting glucose between 150 and 400 mg / dL were considered to have type 2 diabetes. HIIT protocol and gavage performed for eight weeks, five sessions per week with 2-minute alternation of 2 and 8 intervals with 80 to 90% vo2max and a one-minute rest cycle with 50 to 56% vo2max. Royal Jelly was given by gavage at a dose of 100 mg / kg 5 days a week.
Results: Data analysis using two-way analysis of variance test showed that in comparison with the control group, HIIT led to a significant reduction in glucose and insulin resistance index.so data shown that a significant increase in soleuse mascle GLUT4 gene expression compared to the control group and HIIT and royal jelly (P = 0.001).
Conclusion: HIIT and royal jelly were effective in reducing insulin resistance index and expression of genes effective in glucose consumption in soleus muscle. Also, HIIT and royal jelly led to an increase in GLUT4 gene expression in the soleus muscle compared to the control group, which is important in glucose consumption in diabetics.
Methods: The statistical subject consisted of wistar rats became diabetic after a 20 weeks high-fat diet by intraperitoneal injection of 25 mg/kg STZ. Rats with fasting glucose between 150 and 400 mg / dL were considered to have type 2 diabetes. HIIT protocol and gavage performed for eight weeks, five sessions per week with 2-minute alternation of 2 and 8 intervals with 80 to 90% vo2max and a one-minute rest cycle with 50 to 56% vo2max. Royal Jelly was given by gavage at a dose of 100 mg / kg 5 days a week.
Results: Data analysis using two-way analysis of variance test showed that in comparison with the control group, HIIT led to a significant reduction in glucose and insulin resistance index.so data shown that a significant increase in soleuse mascle GLUT4 gene expression compared to the control group and HIIT and royal jelly (P = 0.001).
Conclusion: HIIT and royal jelly were effective in reducing insulin resistance index and expression of genes effective in glucose consumption in soleus muscle. Also, HIIT and royal jelly led to an increase in GLUT4 gene expression in the soleus muscle compared to the control group, which is important in glucose consumption in diabetics.
Type of Study: Research |
Subject:
Special
Received: 2024/05/30 | Accepted: 2024/11/20 | Published: 2025/02/28
Received: 2024/05/30 | Accepted: 2024/11/20 | Published: 2025/02/28
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