Volume 16, Issue 3 (3-2017)                   ijdld 2017, 16(3): 157-163 | Back to browse issues page

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Asgarbeik S, Mohammad amoli M, Angaji S A, Razi F, Nasli esfahani E. ASSOCIATION OF C677T MTHFRGENE POLYMORPHISM WITH DIABETIC NEPHROPATHY. ijdld. 2017; 16 (3) :157-163
URL: http://ijdld.tums.ac.ir/article-1-5633-en.html
1- Department of Cellular and Molecular Biology, Faculty of Biological Sciences, KharazmiUniversity, Tehran, Iran
2- Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , amolimm@tums.ac.ir
3- Diabetes Researcher Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (3194 Views)
Background: Diabetic Nephropathy is one of the main microvascular complications of diabetic mellitus. Methylenetetrahydrofolate Reductase (MTHFR) is one of the candidate genes of diabetic nephropathy. MTHFR (C677T) polymorphism reduces catalytic activity of MTHFR and leads to increase level of plasma homocysteine. The aim of this study was to evaluate the association of C677T polymorphism with diabetic nephropathy.
Methods: In this case control study, 300 individuals, including type 2 diabetes mellitus with diabetic nephropathy (N=104), diabetes mellitus patients without diabetic nephropathy (N=100) and controls (N=96) participated. The MTHFR genotype was determined using PCR-RFLP technique and biochemical parameters were measured.
Results: Genotype frequencies were significantly different between patients with diabetic nephropathy and diabetes mellitus without nephropathy (TT+CT vs CC; P=0.02,OR:0.5,CI:0.3-0.9).The allele frequency was also significantly different between diabetic nephropathy and diabetics mellitus without nephropathy(P=0.013,OR:1.754,CI:1.123-2.740).
Conclusion: These findings suggest that there is an association between C677T polymorphism and nephropathy in patients with type 2 diabetes. Allele C increase the risk of nephropathy, and T allele has a protective role in susceptibility to disease.
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Type of Study: Research | Subject: Special
Received: 2017/07/17 | Accepted: 2017/09/26 | Published: 2017/09/28

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