Volume 23, Issue 3 (9-2023)
ijdld 2023, 23(3): 191-198 |
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Farnaz Onsori1 
, Mina Akbari Rad2 , Maryam Emadzadeh3 , Ali Moradi3 , Mohammad-Javad Mojahedi4 , Alireza Shariati2 , Mohammad-Ali Yaghoubi * 5
, Mina Akbari Rad2 , Maryam Emadzadeh3 , Ali Moradi3 , Mohammad-Javad Mojahedi4 , Alireza Shariati2 , Mohammad-Ali Yaghoubi * 5
1- Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3- Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5- Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ,yaghoubima@mums.ac.ir
2- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3- Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4- Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5- Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (342 Views)
Background: Diabetic nephropathy is the main cause of end-stage kidney disease in diabetic patients. Several inflammatory markers related with diabetic nephropathy have been investigated so far. It is necessary to identify easily available and cost-effective indices. We aimed to determine the relationship between the neutrophil to lymphocyte ratio and mean platelet volume with diabetic nephropathy.
Methods: This cross-sectional study was performed from 2021 to 2022 in diabetes clinic of Ghaem hospital, Mashhad. Patients with type II diabetes were categorized into two groups: without and with nephropathy (urinary albumin excretion greater than 30 mg/24h or GFR less than 60). Patients’ data, including demographic data, past medical and drug history and lab data were gathered and analyzed.
Results: In total, 100 diabetic patients including 50 with (mean age=64.04±7.40 years) and 50 without nephropathy (mean age=56.06±6.36 years), were studied. Patients with nephropathy were older, had a longer history of diabetes and a higher blood pressure (P < 0.05). However, the distribution of gender, weight, height, and BMI was not significantly different the two groups (P>0.05). The absolute neutrophil count was not significantly different between the two groups (P>0.05), while the mean platelet volume, neutrophil% and neutrophil/lymphocyte ratio were significantly higher in patients with nephropathy (P<0.05).
Conclusion: According to our findings, patients with diabetic nephropathy had higher mean platelet volume, neutrophil%, and neutrophil/lymphocyte ratios compared to diabetic patients without nephropathy.
Methods: This cross-sectional study was performed from 2021 to 2022 in diabetes clinic of Ghaem hospital, Mashhad. Patients with type II diabetes were categorized into two groups: without and with nephropathy (urinary albumin excretion greater than 30 mg/24h or GFR less than 60). Patients’ data, including demographic data, past medical and drug history and lab data were gathered and analyzed.
Results: In total, 100 diabetic patients including 50 with (mean age=64.04±7.40 years) and 50 without nephropathy (mean age=56.06±6.36 years), were studied. Patients with nephropathy were older, had a longer history of diabetes and a higher blood pressure (P < 0.05). However, the distribution of gender, weight, height, and BMI was not significantly different the two groups (P>0.05). The absolute neutrophil count was not significantly different between the two groups (P>0.05), while the mean platelet volume, neutrophil% and neutrophil/lymphocyte ratio were significantly higher in patients with nephropathy (P<0.05).
Conclusion: According to our findings, patients with diabetic nephropathy had higher mean platelet volume, neutrophil%, and neutrophil/lymphocyte ratios compared to diabetic patients without nephropathy.
Type of Study: Research |
Subject:
Special
Received: 2023/04/15 | Accepted: 2023/07/23 | Published: 2023/09/1
Received: 2023/04/15 | Accepted: 2023/07/23 | Published: 2023/09/1
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