1- . Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran , dr.sadeghi85@gmail.com
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3- . Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
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3- . Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
Abstract: (455 Views)
Introduction: Adipogenesis is a dynamic process that leads to the phenotype of mature fat cells and plays a significant role in obesity and diabetes. The present study investigates the effect of Eight –Weeks of High-Intensity Interval Training (HIIT) and L -carnitine Consumption on the expression of BMP7 protein in visceral adipose tissue in diabetic rats.
Methods: In an experimental clinical-intervention study, 50 streptozotocin-induced diabetic rats were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplement and exercise (D + LC + T). The training program consisted of eight weeks, 5 sessions per week (6 to 12 2-minute sessions with an intensity of 85-90% of the maximum speed). The subjects received 30 mg/kg body weight L-carnitine through drinking water. Visceral fat was extracted and the expression level of BMP7 protein was assessed using Western Blotting. Data analysis was performed by one-way ANOVA and Tukey post hoc test at a significant level of (P<0.05).
Results: the results showed that the expression of BMP7, the adipogenesis stimulating protein, in (D+T) and (D+LC+T) groups increased significantly (P<0.001) .
Conclusion: According to the results, it seems that HIIT exercise alone and with L-carnitine Consumption is more effective in increasing the expression of protein associated with adipogenesis in visceral fat. However, a clear statement requires further research in this area.
Keywords: Diabetes, Adipogenesis, L -carnitine, High Intensity Interval Training (HIIT)
Methods: In an experimental clinical-intervention study, 50 streptozotocin-induced diabetic rats were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplement and exercise (D + LC + T). The training program consisted of eight weeks, 5 sessions per week (6 to 12 2-minute sessions with an intensity of 85-90% of the maximum speed). The subjects received 30 mg/kg body weight L-carnitine through drinking water. Visceral fat was extracted and the expression level of BMP7 protein was assessed using Western Blotting. Data analysis was performed by one-way ANOVA and Tukey post hoc test at a significant level of (P<0.05).
Results: the results showed that the expression of BMP7, the adipogenesis stimulating protein, in (D+T) and (D+LC+T) groups increased significantly (P<0.001) .
Conclusion: According to the results, it seems that HIIT exercise alone and with L-carnitine Consumption is more effective in increasing the expression of protein associated with adipogenesis in visceral fat. However, a clear statement requires further research in this area.
Keywords: Diabetes, Adipogenesis, L -carnitine, High Intensity Interval Training (HIIT)
Article number: 6
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