1- Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Arak University, Arak, Iran ,a-saremi@araku.ac.ir
3- Arak University, Arak, Iran
2- Arak University, Arak, Iran ,
3- Arak University, Arak, Iran
Abstract: (94 Views)
Background: Alzheimer's disease is the most common type of dementia, which is associated with progressive loss of memory and reaction to the environment. The aim of this study was to investigate the effect of 12 weeks of resistance training with sumac intake on the serum levels of SIR3, SIR4 and AMPK in Alzheimer's male rats.
Methods: In this experimental study, 35 Wistar rats aged 8-10 weeks and average weight of 230±30 grams were randomly divided into five groups: control, Alzheimer's disease, Alzheimer's disease with sumac supplementation, Alzheimer's disease with resistance training, and Alzheimer's disease with They were divided by resistance training and receiving sumac supplements. To induce Alzheimer's disease, 8 mg/kg of trimethyl tin chloride along with 200 microliters of normal saline were injected into mice. Resistance training was performed for 12 weeks and 5 days a week on a special rat ladder. 48 hours after the last training session, a blood sample was taken. Serum levels of SIR3, SIR4 and AMPK were evaluated by ELISA method. Results: the present research showed that 12 weeks of resistance training increases the levels of SIR3 (P<0.036), SIR4 (P<0.029) and AMPK (P<0.047) in Alzheimer's rats. In addition, adding sumac to the resistance training program had no significant effect on SIR3 (P<0.342) and SIR4 (P<0.99).
Conclusion: Our results suggest that resistance training is associated with improving the levels of sirtuin 3, sirtuin 4 and adenosine monophosphate kinase in Alzheimer's rats, and receiving sumac antioxidant compound does not lead to a doubling of these responses
Methods: In this experimental study, 35 Wistar rats aged 8-10 weeks and average weight of 230±30 grams were randomly divided into five groups: control, Alzheimer's disease, Alzheimer's disease with sumac supplementation, Alzheimer's disease with resistance training, and Alzheimer's disease with They were divided by resistance training and receiving sumac supplements. To induce Alzheimer's disease, 8 mg/kg of trimethyl tin chloride along with 200 microliters of normal saline were injected into mice. Resistance training was performed for 12 weeks and 5 days a week on a special rat ladder. 48 hours after the last training session, a blood sample was taken. Serum levels of SIR3, SIR4 and AMPK were evaluated by ELISA method. Results: the present research showed that 12 weeks of resistance training increases the levels of SIR3 (P<0.036), SIR4 (P<0.029) and AMPK (P<0.047) in Alzheimer's rats. In addition, adding sumac to the resistance training program had no significant effect on SIR3 (P<0.342) and SIR4 (P<0.99).
Conclusion: Our results suggest that resistance training is associated with improving the levels of sirtuin 3, sirtuin 4 and adenosine monophosphate kinase in Alzheimer's rats, and receiving sumac antioxidant compound does not lead to a doubling of these responses
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