Volume 17, Issue 3 (3-2018)                   ijdld 2018, 17(3): 125-129 | Back to browse issues page

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Ebrahimi E, Sadegi sedeh B, Rezvanfar M R. Six-Month-Old Infants Developmental Index Comparison Between Gestational Diabetes Mothers On Insulin And Metformin.. ijdld. 2018; 17 (3) :125-129
URL: http://ijdld.tums.ac.ir/article-1-5606-en.html
1- Department of Internal medicine, Arak university of medical sciences, Arak, Iran
2- Department of Internal medicine, Arak university of medical sciences, Arak, Iran , rezvanfar@arakmu.ac.ir
Abstract:   (2469 Views)
Background: Insulin is first choice for gestational diabetes control, but its needed to frequent injections; one thing that is difficult for pregnant women, so interest to metformin consumption is increased. Metformin easily crosses the placenta and its fetal blood levels is equivalent to the level of the mother's blood. Metformin also easily cross the brain barrier and enter the brain. Possible side effects of metformin compared to insulin on fetus brain development was concerned to design of present study.  
Methods: In this cross-sectional prospective trial, gestational diabetes women were recruited randomly to insulin (64 patients) and metformin (64 patients) groups and compared for pregnancy and neonatal outcome and also six-month-old infancy developmental indexes. The results considered significant if P value was ≤ 0.05.
Results: Six-month body mass index of insulin group women was significantly more than metformin group(P=0.05), but there was not any significant difference in cesarean section, preterm labor, dystocia, preeclampsia and still birth rate between two groups. Also neonatal characteristics, need to admission and six-month-old infancy developmental indexes according to Ages stages questionnaire were no different between two groups.
Conclusion: Metformin consumption in compare to insulin was not associated with maternal, neonatal and six-month-old infancy developmental indexes side effects.
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Type of Study: Research | Subject: Special
Received: 2017/04/30 | Accepted: 2018/03/18 | Published: 2018/10/13

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