HYDRO- ALCOHOLIC EXTRACT OF GREEN WHEAT LEAF ON GLUCOSE AND LIPID PARAMETERS AND OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC MICE

Assadi, Assad; Tati, Parisa; sharifi, Rasul; Nourafcan, Hassan; Mohebalipour, Naser

Volume 17, Issue 1 (3-2018) ijdld 2018, 17(1): 1-12 | Back to browse issues page

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Assadi A, Tati P, sharifi R, Nourafcan H, Mohebalipour N. HYDRO- ALCOHOLIC EXTRACT OF GREEN WHEAT LEAF ON GLUCOSE AND LIPID PARAMETERS AND OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC MICE. ijdld 2018; 17 (1) :1-12
URL: http://ijdld.tums.ac.ir/article-1-5700-en.html

HYDRO- ALCOHOLIC EXTRACT OF GREEN WHEAT LEAF ON GLUCOSE AND LIPID PARAMETERS AND OXIDATIVE STRESS IN ALLOXAN-INDUCED DIABETIC MICE

Assad Assadi¹

, Parisa Tati ^*

², Rasul Sharifi²

, Hassan Nourafcan³

, Naser Mohebalipour⁴

1- Department of Basical science, veterinary group, Miyaneh Branch, Islamic Azad University, Miyaneh, Iran
2- Department of Biochemical, biochemical group, Ahar Branch, Islamic Azad University, Ahar, Iran
3- Medicinal plant group, agricultural department, Miyaneh Branch, Islamic Azad University, Miyaneh, Iran
4- Agronomy and plant breeding group, agricultural department, Miyaneh Branch, Islamic Azad university, Miyaneh, Iran

Abstract: (4543 Views)

Background: Diabetes is one of the most common diseases of the body's endocrine system, Based on present forecasts of its prevalence will increase in human societies. Diabetes mellitus consists of 5 groups, its two major groups: type I diabetes or insulin-dependent and type II diabetes or non-insulin dependent diabetes. The aim of this study was to evaluate the effect of alcoholic extract of green wheat leaves on glucose, cholesterol, triglycerides, LDL, HDL and total antioxidant capacity of blood serum in alloxan-induced diabetic mice.
Methods: In this study, 40 male mice with an average weight of 25-20 grams in eight groups of five rats: The negative control, positive control (sham), Methformin (60mg/kg), green Wheat leaf extract (100, 200, 400, 800 and 1000mg/kg) were tested. Blood glucose was measured at baseline, then in the positive control group and the experimental groups by Alloxan (120mg/kg) Diabetes was induced by intraperitoneally. During the study, the positive control group and experimental groups received aforementioned compounds for 10 days via intraperitoneally and after 48 hours of each group blood samples were taken through the intraventricular anesthesia and glucose, cholesterol, triglycerides, LDL, HDL and total antioxidant capacity in serum were measured. Quantitative results achieved in this research by one-way ANOVA and Tukey post hoc test between the groups studied Considering the significance level of p <% 5 were analyzed.
Results: The results showed that blood glucose changes in green Wheat leaf extract and metformin groups compared with the positive control group and negative control group was significant at the 5% level and In all under study groups blood glucose levels, Compared with the positive control group decreased and is close to the negative control group also in doses of 100, 200, 800 and 1000 mg/kg Reduced blood glucose is better than methformin group. Methformin and green Wheat leaf extract caused a significant increase at all doses studied in the TAC's Blood. Methformin and green Wheat leaf extract on the amounts of LDL, HDL and cholesterol in diabetic groups had no significant effect and did not have significant difference with other groups. There was no significant effect of different doses of green Wheat leaf extract on the blood triglycerides. However, metformin has a significant impact on triglyceride levels.
Conclusion: The results of the effects of green Wheat leaf extract on glucose and serum antioxidant capacity
It can be noted that these extracts in the treatment of diabetes and reduce its complications can be considered as an option.