Volume 17, Issue 6 (10-2018)                   ijdld 2018, 17(6): 293-299 | Back to browse issues page

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Hajizadeh moghaddam A, Ahmadalizadeh M, Seyrafi R, Aghagolzadeh M, Khanjani S. EFFECT OF NANOCURCUMIN ON OXIDATIVE STRESS INDICES AND TISSUE CHANGES OF SMALL INTESTINE IN DIABETIC MICE. ijdld. 2018; 17 (6) :293-299
URL: http://ijdld.tums.ac.ir/article-1-5713-en.html
1- Department of Biology, School of Basic Sciences, Mazandaran University, Babolsar, Iran , a.hajizadeh@umz.ac.ir
2- Department of Biology, School of Basic Sciences, Mazandaran University, Babolsar, Iran
3- Department of Pathobiology, School of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
4- School of Biological Sciences, Shahid Beheshti University,Tehran, Iran
Abstract:   (1947 Views)
Background: Diabetes mellitus is a worldwide prevalence of metabolic diseases and its important complications are gastrointestinal disturbances. A wide range of studies have been conducted on the physicochemical traits and pharmacological effects of curcumin on different diseases like diabetes and cancer. However, the poor oral bioavailability and instability of curcumin had greatly limited its further applications. The purpose of this study was to evaluate the effects of Nanocurcumin on the oxidative stress and tissue changes of small intestine in diabetic mice.
Methods: In this experimental study, animals were divided to five groups: Control, sham, diabetic (Intraperitoneal injection of 120 mg/kg of Streptozotocin) and diabetic groups treated with Nanocurcumin (7.5 and 15 mg/kg body weight) for 21days. At the end of experiment, catalase (CAT) activity and Malondialdehyde (MDA) level were measured in intestinal tissue. For histological assessment, villi length and crypt depth in small intestine were investigated.
Results: The oral administration of Nanocurcumin significantly increased intestinal CAT activity (P<0.05) and decreased MDA level (P<0.001). Also, the Villi length in diabetic groups treated with Nanocurcumin showed a significant increase compared to diabetic group (P<0.05).
Conclusion: The findings of this study showed that Nanocurcumin has a protective effect on diabetes-induced digestive disorders due to its antioxidant properties.
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Type of Study: Research | Subject: Special
Received: 2018/05/6 | Accepted: 2018/11/3 | Published: 2018/10/15

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