Volume 24, Issue 1 (3-2024)
ijdld 2024, 24(1): 68-76 |
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Ghodratnama A, Sharifi Rayeni M, Rastegari A, Moayedi R. The Effect of Moderate Intensity Interval Training on Total and Phosphorylated Content of C-Jun N-Terminal Kinases Protein in Heart Tissue of Type 1 Diabetic Rats. ijdld 2024; 24 (1) :68-76
URL: http://ijdld.tums.ac.ir/article-1-6294-en.html
URL: http://ijdld.tums.ac.ir/article-1-6294-en.html
1- Department of Sport Sciences, Apadana Institute of Higher Education, Shiraz, Iran
2- Department of Sport Sciences, School of Education and Psychology, Shiraz university, Shiraz, Iran , sharifimahya73@gmail.com
3- Department of Sports Physiology, Faculty of physical and Sports Sciences, University of Tehran, Tehran, Iran
2- Department of Sport Sciences, School of Education and Psychology, Shiraz university, Shiraz, Iran , sharifimahya73@gmail.com
3- Department of Sports Physiology, Faculty of physical and Sports Sciences, University of Tehran, Tehran, Iran
Abstract: (153 Views)
Background: Cardiac function in diabetic people is affected through different cellular mechanisms; One of these important cellular pathways is the c-Jun N-terminal kinases (JNKs), whose dysfunction can lead to heart failure; Therefore, the aim of this research is to investigate the effect of moderate intensity interval training on total and phosphorylated content of c-Jun N-terminal kinases protein in heart tissue of type 1 diabetic rats.
Methods: In this experimental study, 12 two-month-old male Sprague Dawley rats with an average weight of 300±20 grams were selected. Type 1 diabetes (blood sugar above 300) was induced to rats through intraperitoneal injection of streptozotocin (with a dose of 50 mg per kilogram of body weight) solution. The rats were randomly divided into two groups, diabetic training and diabetic control; The training group performed MIIT for four weeks at an intensity of 55-75% of maximum speed. Data analysis was done through independent t-test in GraphPad Prism software version 9.5. The significance level of the current research is P≤ 0.05.
Results: The intracellular content of JNK protein after four weeks of MIIT showed a significant decrease in both total (P= 0.01) and phosphorylated (P= 0.0001) forms. On the other hand, the ratio of total to phosphorylated intracellular content of JNK protein did not show a significant change after four weeks of MIIT (P= 0.23).
Conclusion: MIIT led to a decrease in the content of total and phosphorylated forms of JNK protein, which could possibly lead to less cell death in cardiac cells of diabetic subjects.
Methods: In this experimental study, 12 two-month-old male Sprague Dawley rats with an average weight of 300±20 grams were selected. Type 1 diabetes (blood sugar above 300) was induced to rats through intraperitoneal injection of streptozotocin (with a dose of 50 mg per kilogram of body weight) solution. The rats were randomly divided into two groups, diabetic training and diabetic control; The training group performed MIIT for four weeks at an intensity of 55-75% of maximum speed. Data analysis was done through independent t-test in GraphPad Prism software version 9.5. The significance level of the current research is P≤ 0.05.
Results: The intracellular content of JNK protein after four weeks of MIIT showed a significant decrease in both total (P= 0.01) and phosphorylated (P= 0.0001) forms. On the other hand, the ratio of total to phosphorylated intracellular content of JNK protein did not show a significant change after four weeks of MIIT (P= 0.23).
Conclusion: MIIT led to a decrease in the content of total and phosphorylated forms of JNK protein, which could possibly lead to less cell death in cardiac cells of diabetic subjects.
Keywords: Moderate Intensity Interval Training, Type 1 Diabetes, c-Jun N-terminal Kinases, Left Ventricle
Type of Study: Research |
Subject:
General
Received: 2023/10/2 | Accepted: 2024/01/10 | Published: 2024/03/29
Received: 2023/10/2 | Accepted: 2024/01/10 | Published: 2024/03/29
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